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On the understanding that few people ever read the preface to any
book and also on the understanding that even those few people who
do read the preface realize that virtually nothing of any substance
is ever said, I shall write at such length as will be proportional
to my expected readership. The meetings of the International
Society on Oxygen Transport to Tissue provide a forum for
discussion amongst scientists who, although being from very diverse
and specialized backgrounds, have tissue oxygenation as a unifying
theme of interest. The wide variety of research material presented
in this volume and the multiplicity of the experimental techniques
described, should serve as an adequate gauge to the range of
expertise and knowledge of the society's members. Such diversity
should also stress the importance of the need for multidisciplinary
approaches to complex biological problems. In attempting a
fundamental characterization of a biological process such as tissue
oxygenation, the application of very many separate research skills
are necessary, such as mathematics, engi neering, biophysics,
biochemistry, physiology, histology and clini cal medicine. The
success of the ISOTT has - and we hope - will con tinue to be
causing a combination of individuals to direct their specialized
knowledge to the many facets of a single proces- tissue
oxygenation."
The first International Symposium on Theory and Applica- tion of
Ion and Enzyme Electrodes in Biology and Medicine was organized at
SchloB Reisensburg near Ulm in 1974. The concept of this meeting
was to discuss the theory and applica- tion of carrier operated
electrodes within an interdisciplinary group of investigators
coming from physical chemistry, or- ganic chemistry, physiology,
biochemistry and medicine. Be- cause of its interdisciplinary
character, the Symposium proved to be very productive and further
meetings based on the same principle were held at the
Max-Planck-Institut fUr Systemphysiologie in Dortmund in 1977 and
1980. For the 1983 meeting it was decided to return to the ethe-
real atmosphere of a castle (Burg Rabenstein) set in the beau-
tiful surroundings of Swiss Franconia. Participation was re-
stricted to those involved in the theoretical, experimental and
clinical applications of ion selective electrodes. In this way a
critical mass was achieved whereby an infor- mation transfer was
induced between groups who had previ- ously had little or no
communication with each other. We hope that this interdisciplinary
spirit may encourage and stimulate those scientists and clinicians
who are considering entering the field of ion investigations and
that this book may serve as a compendium of current ion selective
electrode methodology and ideas, together with their application in
the- oretical fields, physiology and medicine.
Proceedings of the Meeting on Theory and Application of Ion
Selective Electrodes in Physiology and Medicine, held at Dortmund
on July 28-30, 1980
It is becoming traditional that periodically those of us interested
in the carotid body hold an international meeting to discuss their
results. In 1966 a meeting was organized by R. W. Torrance in
Oxford and in 1973 by M. J. Purves in Bristol; in 1974 A. S.
Paintal organized a satellite symposium of the Physiological
Congress in Kashmir. The organizers of these meetings are to be
commended for their efforts in publishing both the papers and
discussions. At these meetings it has become apparent that the
direction of research is becoming more sharpely focused on the
cellular mechanisms of chemoreception. During the meeting in
Dortmund the papers dealt mostly with the different cell types in
the carotid body and their environment, i. e., local P0 and local
flow. These included 2 light and electron microscopic studies of
the morphometric and histochemical pro perties of the different
cells, microelectrode studies of the glomoid tissue to understand
the conversion of a chemical stimulation into nervous activity, as
well as strictly bio chemical and physiologic investigations
concerning the dependence of the chemo receptive process on O
consumption and the turnover of catecholamines. In spite 2 of the
variety in methodology, it was apparent that all contributors had a
common interest: to understand the mechanisms of chemoreception.
Although at the meeting itself there was ample time to fully
discuss the various papers, it has become necessary here to shorten
the papers and discussions; otherwise the cost of publication would
have been prohibitive."
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