Many companies recognize the importance of corporate social responsibility, but seek to understand how this can be harmonized with current profitability. This new approach, drawing upon many contemporary examples, demonstrates the importance of balancing short term profitability with long term sustainability and shows how this relates to many business issues and aspects including environmental change, ethical trading, corporate governance, risk management, sustainable development and competitive balance.

This Technical Report presents the outcome of a Working Group that was established to determine broadly applicable sound exposure guidelines for fishes and sea turtles. After consideration of the diversity of fish and sea turtles, guidelines were developed for broad groups of animals, defined by the way they detect sound. Different sound sources were considered in terms of their acoustic characteristics and appropriate metrics defined for measurement of the received levels. The resultant sound exposure guidelines are presented in a set of tables. In some cases numerical guidelines are provided, expressed in appropriate metrics. When there were insufficient data to support numerical values, the "relative "likelihood of effects occurring was evaluated, although the "actual" likelihood of effects depends on the received level. These sound exposure guidelines, which are based on the best scientific information at the time of writing, should be treated as interim. The expectation is that with more research the guidelines can be refined and more cells in the tables completed. Recommendations are put forward defining the research requirements of highest priority for extending these interim exposure guidelines.

Many companies recognize the importance of corporate social responsibility, but seek to understand how this can be harmonized with current profitability. This new approach draws upon many contemporary examples to show how to balance short term profitability with long term sustainability.

Our pocket-book has come about as a direct attempt to answer the needs of our clinical students. We have tried to use radiology as a magic window for looking at their patients' medical and surgical problems. The book is very simple and highly selective. A number of excellent introductory texts already exist for students seeking comprehensive and balanced accounts of radiology as a specialty. We have tried to keep close to our title: a good guide shows you a bare outline of where you might go, and makes sure you see the highlights. He will point to interesting places that deserve study, without going into them himself. Occasionally he may enlarge on a topic when the information is not readily available anywhere else (as in our chapter on the skull). And he will be ready to listen to students asking, perhaps rather shyly, some basic questions (as in our first and last chapters). We have taken Voltaire as our own guide: "Le secret d'ennuyer est . . . de tout dire." The book has been written by only a small group of all those teaching radiology at Cambridge. We wish to absolve our colleagues from all blame, and to thank them for generous support, especially in the loan of illustrations. Cambridge, 1982 Thomas Sherwood Contents 1. Introduction: Medicine and Radiology Thomas Sherwood. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 2. Diagnosis Thomas Sherwood. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 Looking at an x-ray. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 Diagnostic pathways . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 Sensitivity and specificity of tests . . . . . . . . . . . . . . . . . . . . . 14 Conclusion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 3. Bones Thomas Sherwood. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

The problem of outliers is one of the oldest in statistics, and during the last century and a half interest in it has waxed and waned several times. Currently it is once again an active research area after some years of relative neglect, and recent work has solved a number of old problems in outlier theory, and identified new ones. The major results are, however, scattered amongst many journal articles, and for some time there has been a clear need to bring them together in one place. That was the original intention of this monograph: but during execution it became clear that the existing theory of outliers was deficient in several areas, and so the monograph also contains a number of new results and conjectures. In view of the enormous volume ofliterature on the outlier problem and its cousins, no attempt has been made to make the coverage exhaustive. The material is concerned almost entirely with the use of outlier tests that are known (or may reasonably be expected) to be optimal in some way. Such topics as robust estimation are largely ignored, being covered more adequately in other sources. The numerous ad hoc statistics proposed in the early work on the grounds of intuitive appeal or computational simplicity also are not discussed in any detail.

This book, first published in 1996, is a concise yet fully informative coverage of the structure and function of genes. It describes DNA and how it replicates, how DNA is transcribed and translated into proteins, the organisation of genes in prokaryotes and eukaryotes, the control of gene expression and the role of retroviruses and oncogenes in cancer. There are additional discussions of gene families, genes and the immune systems and mitochondrial and chloroplast genomes. This is a third edition of a successful undergraduate text. It has been extensively updated, particularly in regard to advances in our understanding of replication and transcription.

This new edition of a highly successful undergraduate text is a concise yet fully informative guide to the structure and function of genes. It describes DNA and how it replicates, how DNA is transcribed and translated into proteins, the organization of genes in prokaryotes and eukaryotes, the control of gene expression, and the role of retroviruses and oncogenes in cancer. There are additional discussions of gene families, genes and the immune systems, and mitochondrial and chloroplast genomes. The new edition has been extensively updated, particularly in regard to recent advances in our understanding of replication and transcription. Undergraduates studying genetics will benefit from this established text.