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There has always been some tension between proponents of
hypothesis-driven and discovery-driven research in the broad field
of life sciences. Academic research has been primarily focused on
hypothesis-driven research. However, the success of the human
genome project, a discovery-driven research approach, has opened
the door to adding other types of discovery-driven research to a
continuum of research approaches. In contrast, drug discovery
research in the pharmaceutical industry has embraced
discovery-driven research for many years. A good example has been
the discovery of active compounds from large chemical libraries,
through screening campaigns. The success of the human genome
project has also demonstrated the need for both academic
researchers and industrial researchers to now understand the
functions of genes and gene products. The cell is the basic unit of
life and it has been at the cellular level where function can be
demonstrated most cost-effectively and rapidly. High content
screening (HCS) was developed by Cellomics Inc. in the mid-1990s to
address the need for a platform that could be used in the
discovery-driven research and development required to understand
the functions of genes and gene products at the level of the cell.
There has always been some tension between proponents of
hypothesis-driven and discovery-driven research in the broad field
of life sciences. Academic research has been primarily focused on
hypothesis-driven research. However, the success of the human
genome project, a discovery-driven research approach, has opened
the door to adding other types of discovery-driven research to a
continuum of research approaches. In contrast, drug discovery
research in the pharmaceutical industry has embraced
discovery-driven research for many years. A good example has been
the discovery of active compounds from large chemical libraries,
through screening campaigns. The success of the human genome
project has also demonstrated the need for both academic
researchers and industrial researchers to now understand the
functions of genes and gene products. The cell is the basic unit of
life and it has been at the cellular level where function can be
demonstrated most cost-effectively and rapidly. High content
screening (HCS) was developed by Cellomics Inc. in the mid-1990s to
address the need for a platform that could be used in the
discovery-driven research and development required to understand
the functions of genes and gene products at the level of the cell.
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