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The present volume does not deal with a single chemical but with
three solvents and three propellants that are likely to be used in
aerosol products. Although it is common practice to combine
solvents and propellants in pressurized containers, there has been
no previous attempt to examine each constituent singly and in
combination.
In the present and subsequent volumes of this book, critical
coverage of the literature will be combined with the fruits of
original and highly relevant research carried out by Dr. D.M Aviado
and his colleagues. The total effort constitutes an authoritative
up-to-date appraisal of the knowledge needed to understand the
inhalational toxicity and other biological effects of an important
and ubiquitous class of chemical agents.
D.A. KHARKEVICH The history of the study of ganglionic substances
begins with the paper of LANGLEY and DICKINSON (1889), who
established the ability of nicotine to block the neurones in the
superior cervical ganglion. This was a considerable discovery as
the authors ascertained that impulses were transmitted from pre- to
postganglionic neurones in the autonomic ganglia. Simultaneously
they indicated the possibility of pharmaco logical influence upon
interneuronal transmission in autonomic ganglia. The idea of
ganglionic receptors specifically sensitive to nicotine followed
logically. Later, LANGLEY (1905, 1906) considered the problem of
receptors with respect to neuro-effector synapses. It is remarkable
that he was one of the first to put forward the theory of chemical
mediation of excitation (" ... the nervous impulse should not pass
from nerve to muscle by an electric discharge, but by the secretion
of a special substance at the end of the nerve" LANGLEY, 1906, p.
183). In addition, LANGLEY JOHN N. LANGLEY (1852-1926) D.A.
KHARKEVICH 2 and his collaborators managed to define the topography
of autonomic ganglia more precisely by means of nicotine. It should
be mentioned that it was he who introduced the terms "autonomic
nervous system" and "parasympathetic nervous system.""
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