The series "Topics in Heterocyclic Chemistry" will present critical reviews on "Heterocyclic Compounds" within topic related volumes dealing with all aspects such as synthesis, reaction mechanisms, structure complexity, properties, reactivity, stability, fundamental and theoretical studies, biology, biomedical studies, pharmacological aspects, applications in material sciences etc. Metabolism will be also included which will provide information useful in designing pharmacologically active agents. Pathways involving destruction of heterocyclic ring will also be dealt with so that synthesis of specifically functionalized non-heterocyclic molecules can be designed. Overall scope is to cover topics dealing with most of the areas of current trends in heterocyclic chemistry which will suit to a larger heterocyclic community.

T. Brown, H. Holt Jr., M. Lee: Synthesis of Biologically Active Heterocyclic Stilbene and Chalcone Analogs of Combretastatin.- J.T. Gupton: Pyrrole Natural Products with Antitumor Properties.- Brian E. Love: Synthesis of Carbolines Possessing Antitumor Activity.- D.P. Arya: Diazo and Diazonium DNA Cleavage Agents: Studies on Model Systems and Natural Product Mechanisms of Action.- M. Daneshtalab: Novel Synthetic Antibacterial Agents.- S.N. Maiti, R.P. Kamalesh Babu, R. Shan: Overcoming Bacterial Resistance: Role of ss-Lactamase Inhibitors

Advances that open new avenues in developing aminoglycoside antibiotics

During the last twenty years, there have been numerous advances in the understanding of the chemistry, biochemistry, and recognition of aminoglycosides. This has led to the development of novel antibiotics and opened up new therapeutic targets for intervention. This is the first book to provide a complete overview of recent advances in the field and explore their tremendous potential for drug discovery and rational drug design. With chapters written by one or more leading experts in their specialty areas, the book addresses the chemistry, biology, and toxicology of aminoglycosides.

"Aminoglycoside Antibiotics: From Chemical Biology to Drug Discovery" is a great resource for academic and industrial researchers in drug design and mechanism studies and for researchers studying antibiotic resistance, antibiotic design and synthesis, and the discovery of novel pharmaceuticals. It is also a valuable reference for graduate students in pharmacy, pharmaceutical science, biophysics, medicinal chemistry, and chemical biology.