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A compilation of researchers' experience in the areas of
bioanalysis, pharmacokinetics, and drug metabolism, to present an
up-to-date and comprehensive treatise on the application of these
and related technologies in drug discovery, development, and
clinical use. Contents cover descriptions of analytical methods, in
vitro metabolism technology and membrane transport, reappraisal of
classical pharmacokinetic problems, and the time course of drug
action. The book concludes with a description of PET and imaging
methods in pharmacokinetics and an appendix containing a critical
appraisal of computer methods and pharmacokinetic software
available for PCs.
The desirability of quality-assay of ingestable or imbibable
material has resulted in an established procedure in advanced
countries. Testimony to its necessity was borne by the scandal of
chateau-bottled Bordeaux crus classes a few years ago, a litigation
instigated by the disillusioned consumers who either on the basis
of absence of the expected inebriate state, or of the
olfacto-gustatory caress by the bouquet or full-bodied lingering
pharyngeal sensation, decided to strike a paranoid attitude, which
ultimately proved to be justified. When one proceeds from sheer
pleasure to dire necessity, the question of what happens to
ingested medication assumes quite portentous features. Testimony is
borne to this by the transitional stage, at which one is faced with
the legal consequences of the basically illegal alcohol-respiration
test, based on the relationship between the amount of ingested
alcohol and the C Hs OH concentration in expired air or in venous
blood, a wholly uncon 2 stitutional terror, in view of the Rome
treaty signed by the Western coun tries, which says that nobody
should be required to cooperate in procedures aimed at providing
him guilty. On top of this, the lamentable fact is observ able,
that among the professio nobile there are even those who took the
oath of Hippocrates and lend their hands, not to cure (as they
promised), but to perform a cubital vein puncture in order to prove
someone, who is not their patient, guilty."
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