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INTRODUCTION AND RATIONALE FOR INTRACELLULAR CHOLESTEROL
TRAFFICKING This volume is an elaboration of an earlier small
meeting held in St. Louis, Missouri. In April 1997, many of the
authors met for a two-day meeting devoted entirely to intracellular
cholesterol trafficking. The rationale for this meeting was that
investigators interested in this topic worked in a variety of
fields, and rarely, if ever, all met together. Everybody knew each
other's papers but mostly worked in isolation from one another.
Understanding of cholesterol trafficking also appeared to have
reached the point where it would start to rapidly expand beyond
these few laboratories. Understanding of cholesterol trafficking
was moving from a largely descriptive science into the molecular
age. It seemed a good time to get together and see how much we
agreed upon up to this point. More authors contributed to this
volume than attended the St. Louis meeting. That meeting was
generously funded by grants from Bristol-Myers Squibb, Merck and
Company and Parke-Davis, however, the total funding available
limited the size of the meeting. For the book, we are not so
limited and have tried to be as inclusive as possible and pretty
much invited everyone who is presently active in this area. We were
quite fortunate to successfully recruit the authors we sought for
each of these chapters. The authors and their contributions can be
organized by particular interests and particular areas of
expertise.
The current understanding of cholesterol transport has moved from a
largely descriptive science into the molecular stage. Intracellular
Cholesterol Trafficking reports on the current state of research
and features sections on: The Regulation of ACAT and Intracellular
Cholesterol Level Niemann-Pick Type C Disease Cholesterol Transport
in Specialized Cells Sterol Carrier Protein-2 and Cholesterol
Transport Proteins Caveolae and Caveolin Summary and Future
Perspectives . Intracellular Cholesterol Trafficking is sure to
appeal to cell biologists, biochemists, endocrinologists,
hepatologists, and atherosclerosis researchers.
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