Cardiovascular diseases (CVDs) are the leading cause of death worldwide today, but are not just a modern phenomenon. To explore the deep roots of CVDs in human history, this book, for the first time, brings together bioarchaeological evidence from different periods, as old as 5000 BC, and geographic locations from Alaska to Northern Africa. Experts in their fields showcase the powerful tool set available to bioarchaeology, which allows a more comprehensive reconstruction of the human past through evidence for disease. The tools include aDNA and histological analyses and digital imaging techniques for studying skeletal and mummified human remains. The insights gained from these studies are not only of value to historical research but also demonstrate how the science of archaeological human remains can provide the long view of the history of disease and contributes to modern biomedical research within the context of evolutionary medicine.