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Infectious diseases have plagued man throughout history. In the era
of modern medicine antibiotics and vaccines brought the hope of
liberation from the great scourges of smallpox, polio, and
tuberculosis. Yet, in the ensuing decades as we hoped to close the
book on infectious diseases, we have instead been confronted by
wave upon wave of new assailants. AIDS, SARS, pandemic influenza,
and multi-drug resistant bacteria demonstrated how our
technological advances have either fallen short in halting or even
enhanced the spread of emerging pathogens. International air travel
has collapsed geographic boundaries that once confined tropical
infections to distant latitudes. Novel forms of immunosuppression,
advances in organ transplantation, and victories in the cancer wars
have led to an ever-expanding population at risk for opportunistic
infections. In this collection of illustrated cases we give a
cross-sectional view of the growing challenges that face the
infectious diseases consultant. The modern physician is empowered
by high resolution imaging and molecular diagnostic techniques that
confer diagnostic capabilities Osler could have only dreamed of.
Nevertheless we continue to grapple with the timeless struggles
illuminated by Pasteur, Koch, and Fleming between man and the
microscopic organisms of the world.
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