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Over the past decade, neuroproteomics has shed light on the
molecular features of schizophrenia by depicting biological
processes involved with its establishment, maintenance and
treatment. These studies have also pointed to potential biomarkers
applicable to diagnosis and medication monitoring. Edited by a
leader in the field of neuroproteomics with contributions from
subject experts, this new volume will address recent findings and
compile evidence from difference perspectives-such as human
samples, animal models, pluripotent stem cell-derived in vitro
pre-clinical models-and provide findings to inform the development
of innovative future treatment strategies. This volume will be
useful for a broad audience of researchers and professionals,
including biologists, neurologists, psychiatrists, analytical
chemists, and pharmacists, among others.
Shotgun Proteomics: Methods and Protocols serves as a vital
collection of protocols through which thousands of proteins can be
simultaneously identified, quantified and characterized in a high
throughput manner. Beginning with the history of proteomics
centered on the vital role of mass spectrometry in its development,
this detailed volume continues with chapters on sample
pre-fractionation, in vivo and in vitro stable isotope labeling,
label-free proteomics, informatics, protein-protein interactions,
targeted proteomics and post-translational modifications. Written
for the highly successful Methods in Molecular Biology series,
chapters include introductions to their respective topics, lists of
the necessary materials and reagents, step-by-step, readily
reproducible laboratory protocols and tips on troubleshooting and
avoiding known pitfalls. Practical and comprehensive, Shotgun
Proteomics: Methods and Protocols is an ideal and up-to-date guide
for researchers seeking to understand the proteome of any given
species.
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