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The idea for this book arose during the 1985 Gordon Conference on
"Mammary Gland Biology." New developments in the methodology of
cell biology and the explosive growth of molecular biology had
begun to impact upon our understanding of mammary gland growth and
function. It seemed a propitious time for summarizing the current
status of knowledge of the cell and molecular biology of mammary
cancer and for attempting to outline future areas of concern and
interest. The reviews presented here were completed by the Fall of
1986. Although new insights will surely continue to emerge, it is
hoped that the material in this volume will form not only a current
update but a basic core of information for future experiments. We
have not attempted to cover all areas of mammary gland
transformation. Those areas where recent detailed reviews are
already available have been omitted. Also, the areas of normal
gland development, cell ultrastructure, hormone responsiveness,
chemotherapy and clinical aspects of mammary cancer have not been
included. Instead, we have selected those areas where the
development of new methodology, reagents and results have led to
new ideas about mammary gland function and development as they are
related to neoplasia.
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