This book presents the statistical aspects of designing, analyzing and interpreting the results of genome-wide association scans (GWAS studies) for genetic causes of disease using unrelated subjects. Particular detail is given to the practical aspects of employing the bioinformatics and data handling methods necessary to prepare data for statistical analysis. The goal in writing this book is to give statisticians, epidemiologists, and students in these fields the tools to design a powerful genome-wide study based on current technology. The other part of this is showing readers how to conduct analysis of the created study.

Design and Analysis of Genome-Wide Association Studies provides a compendium of well-established statistical methods based upon single SNP associations. It also provides an introduction to more advanced statistical methods and issues. Knowing that technology, for instance large scale SNP arrays, is quickly changing, this text has significant lessons for future use with sequencing data. Emphasis on statistical concepts that apply to the problem of finding disease associations irrespective of the technology ensures its future applications. The author includes current bioinformatics tools while outlining the tools that will be required for use with extensive databases from future large scale sequencing projects. The author includes current bioinformatics tools while outlining additional issues and needs arising from the extensive databases from future large scale sequencing projects.

Cancer Epidemiology in Asian Americans is a comprehensive volume that provides the most current research on cancer etiology within this fast growing population sub-group in the United States. The book explores epidemiologic methods that are typically used in migrant studies, providing descriptive epidemiology of cancer patterns separately in Chinese, Japanese, Filipino and other Asian ethnic groups including Asian Indians, Koreans, Vietnamese, and other Southeast Asians. A major focus of the volume provides reviews of analytic risk factors for specific cancer sites including lung, colorectal, prostate, breast, liver and more. These chapters aim to explain the increases or decreases in incidence rates of various cancers upon migration, paying attention to changing risk factor prevalence, the importance of timing of exposures, and other co-factors important in the etiology of these cancers. Genetic determinants and gene-environment relationships associated with specific cancers are also discussed.. This first of its kind volume that is devoted to studies of cancer in Asian Americans provides a foundation to better understanding of environmental and lifestyle causes of cancer in this group, identifying gaps in our knowledge, and potential strategies for prevention.

Cancer Epidemiology in Asian Americans is a comprehensive volume that provides the most current research on cancer etiology within this fast growing population sub-group in the United States. The book explores epidemiologic methods that are typically used in migrant studies, providing descriptive epidemiology of cancer patterns separately in Chinese, Japanese, Filipino and other Asian ethnic groups including Asian Indians, Koreans, Vietnamese, and other Southeast Asians. A major focus of the volume provides reviews of analytic risk factors for specific cancer sites including lung, colorectal, prostate, breast, liver and more. These chapters aim to explain the increases or decreases in incidence rates of various cancers upon migration, paying attention to changing risk factor prevalence, the importance of timing of exposures, and other co-factors important in the etiology of these cancers. Genetic determinants and gene-environment relationships associated with specific cancers are also discussed.. This first of its kind volume that is devoted to studies of cancer in Asian Americans provides a foundation to better understanding of environmental and lifestyle causes of cancer in this group, identifying gaps in our knowledge, and potential strategies for prevention.

This book presents the statistical aspects of designing, analyzing and interpreting the results of genome-wide association scans (GWAS studies) for genetic causes of disease using unrelated subjects. Particular detail is given to the practical aspects of employing the bioinformatics and data handling methods necessary to prepare data for statistical analysis. The goal in writing this book is to give statisticians, epidemiologists, and students in these fields the tools to design a powerful genome-wide study based on current technology. The other part of this is showing readers how to conduct analysis of the created study. Design and Analysis of Genome-Wide Association Studies provides a compendium of well-established statistical methods based upon single SNP associations. It also provides an introduction to more advanced statistical methods and issues. Knowing that technology, for instance large scale SNP arrays, is quickly changing, this text has significant lessons for future use with sequencing data. Emphasis on statistical concepts that apply to the problem of finding disease associations irrespective of the technology ensures its future applications. The author includes current bioinformatics tools while outlining the tools that will be required for use with extensive databases from future large scale sequencing projects. The author includes current bioinformatics tools while outlining additional issues and needs arising from the extensive databases from future large scale sequencing projects.