Peripheral vascular disease (PVD) affects more than 30 million people worldwide, most often individuals over age 65. Despite this, PVD remains a disease with which many clinicians are unfamiliar. This guide to peripheral vascular disease will help medical professionals of different backgrounds and training apply resources adequately to benefit individual patients. The authors provide a description of relevant vascular anatomy and pathophysiology, a focused review of diagnostic modalities used in screening for PVD, and contemporary medical and interventional treatments used for PVD. Generous use of bullet points, condensed tables, high-quality figures, and diagrams facilitate easy comprehension of a multifaceted and serious condition.