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This study assembles current and new information on the mechanisms
involved in intracellular calcium regulation and their actual or
potential relationship to cellular calcium transport. Topics
discussed in detail are calcium channels, cellular calcium
extrusion, sodium/calcium exchange, calcium-binding proteins with
special reference to the vitamin D-induced calbindin, calcium
transport and disorders thereof. Each topic is introduced with an
overview followed by research papers dealing with relevant topics
in each category. New information deals with calcium channels which
are not voltage-sensitive, the structure and function of the plasma
membrane Ca ATPase, the role of the Na/Ca exchanger in
intracellular Na and proton regulation, a comprehensive overview of
calcium transport with quantitative analysis of the role of the
intestinal and renal calcium-binding proteins, description of the
structure and function of the calbindin genes, and identification
of calcium transport defects in diabetes and hypertension. Readers
will be brought up-to-date on current knowledge and concepts in
this rapidly expanding field and be directed to the relevant
primary and secondary literature.
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