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This volume provides a comprehensive collection of experimental
protocols for investigating ferroptosis in different systems,
including cultured cells, animal models, and human tissues. The
techniques covered in this book look at various aspects of
ferroptosis ranging from the detection of lipid peroxidation to the
measurement of glutathione peroxidase activity and the evaluation
of mitochondrial morphology. Chapters also discuss basic molecular
biology methods such as quantitative PCR and immunoblotting, and
advanced imaging techniques such as transmission electron
microscopy and confocal fluorescence microscopy. Written in the
highly successful Methods in Molecular Biology series format,
chapters include introductions to their respective topics, lists of
the necessary materials and reagents, step-by-step, readily
reproducible laboratory protocols, and tips on troubleshooting and
avoiding known pitfalls. Cutting-edge and authoritative,
Ferroptosis: Methods and Protocols is a valuable resource for
researchers who are interested in studying ferroptosis in different
contexts including basic research, drug discovery, and clinical
applications.
This book sheds new light on ferroptosis, as an only recently
recognised form of regulated cell death. Its respective chapters
address the numerous implications that ferroptosis can have for
virtually all aspects of metabolism. They also share insights on
the morphological characterisation of ferroptosis and highlight the
different pathways of induction. Accordingly, the book offers a
unique perspective on a mechanism that is involved in a multitude
of pathologies, including cancer cell death, neurotoxicity,
neurodegenerative diseases, acute renal failure, drug-induced
hepatotoxicity, tissue ischemia/reperfusion injury, and T cell
immunity. Readers will learn in which cell types this form of
regulated cell death is likely to occur, and how it can be
pharmacologically influenced, making the book a fascinating and
informative read not only for scientists working in cell biology,
but also for clinicians in the field of cancer research.
This updated and expanded volume gives new insights on
ferroptosis – an iron-dependent form of non-apoptotic
cell death. The collection of chapters discusses the two major
pathways through which ferroptosis can occur: the extrinsic or
transporter-dependent pathway and the intrinsic or enzyme-regulated
pathway. Readers will gain an understanding of the multiple levels,
on which this special cell death is regulated. Hence, the
contributions will take a closer look at epigenetic,
transcriptional, posttranscriptional and posttranslational layers.
Among the described regulators and transcription factors are GPX4,
ACSL4 and NFE2L2. This edited volume collects reviews related to
current knowledge on the integrated molecular machinery of
ferroptosis, thereby also describing how dysregulated ferroptosis
is involved in human diseases.
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