Carefully designed for use by clinical and pharmaceutical researchers and scientists, Handbook of Regression Analysis and Modeling explores statistical methods that have been adapted into biological applications for the quickly evolving field of biostatistics. The author clearly delineates a six-step method for hypothesis testing using data that mimics real life. Relying heavily on computer software, he includes exploratory data analysis to evaluate the fit of the model to the actual data. The book presents a well-defined procedure for adding or subtracting independent variables to the model variable and covers how to apply statistical forecasting methods to the serially correlated data characteristically found in clinical and pharmaceutical settings. The stand alone chapters allow you to pick and choose which chapter to read first and home in on the information that fits your immediate needs. Each example is presented in computer software format. The author uses MINITAB in the book but supplies instructions for SAS and SPSSX, making the book easily adaptable to individual situations. Although written with the assumption that the reader has knowledge of basic and matrix algebra, the book supplies a short course on matrix algebra in the appendix for those who need it. Covering more than just statistical theory, the book provides advanced methods that you can put to immediate use.

Showcasing a discussion of the experimental process and a review of basic statistics, this volume provides methodologies to identify general data distribution, skewness, and outliers. It features a unique classification of the nonparametric analogs of their parametric counterparts according to the strength of the collected data. Applied Statistical Designs for the Researcher discusses three varieties of the Student t test, including a comparison of two different groups with different variances; two groups with the same variance; and a matched, paired group. It introduces the analysis of variance and Latin Square designs and presents screening approaches to comparing two factors and their interactions.

A range of factors must be considered when developing a topical antimicrobial for use in a healthcare personnel handwash, surgical scrub, or preoperative skin preparation. Antimicrobial effectiveness, low skin irritation, ease of use, and pleasing aesthetics are all essential if the product is to succeed. In addition, all facets of the product must comply with stringent regulatory requirements. With updated protocols and research, Topical Antimicrobials Testing and Evaluation, Second Edition comprehensively presents and reviews the latest techniques for testing antimicrobial compounds for effectiveness and regulatory compliance. Topics include: The anatomical structure of the skin and skin microbiology relevant to product testing Use of antimicrobial products against specific microorganisms such as Staphylococcus and Streptococcus species Measurement of antimicrobial action of topical antimicrobials from experimental design, microbiological, biostatistical, and marketplace perspectives Various aspects of the topical antimicrobial products currently in common use in medical, food service, and consumer markets Statistical analysis and specific statistical designs for clinical trials Epistemological requirements in evaluating the effects of specific treatments Evaluation strategies and sample working protocols for hand and body soaps, food-handler antimicrobial products, and medical/healthcare industry antimicrobial products The book is designed to inform industry and academia on the requirements to get products approved by the FDA and to market while also providing critical insight on ways to best service expanding markets.

Providing industry and academia with the ways of getting products approved by the FDA and the means of servicing expanding markets, this work presents and reviews techniques for testing antibacterial compounds. It discusses and illustrates the most effective methods for testing efficacy and safety of preinjection and preoperative washes, healthcare and food service workers' handwashes, and surgical scrubs.

This reference examines laboratory techniques and FDA and industry perspectives on medical, food service, and consumer product applications of antimicrobials. It offers methods to conduct investigations of effectiveness that simulate use of consumer, food, and medical antimicrobials in real-world conditions and environments, validate neutralizing systems, develop reliable and functional antimicrobial products, and prevent infection, disease, and contamination. Additional topics include the importance of customer-valued quality attributes, such as low skin irritation and ease of use, label claims, regulatory procedures, and quality control, and clinical simulation protocols.

This reference examines laboratory techniques and FDA and industry perspectives on medical, food service, and consumer product applications of antimicrobials. It offers methods to conduct investigations of effectiveness that simulate use of consumer, food, and medical antimicrobials in real-world conditions and environments, validate neutralizing systems, develop reliable and functional antimicrobial products, and prevent infection, disease, and contamination. Additional topics include the importance of customer-valued quality attributes, such as low skin irritation and ease of use, label claims, regulatory procedures, and quality control, and clinical simulation protocols.

From the slippery covering on rocks in a stream, to the clogging slime in a bathtub drain, biofilms are present in everyday life in a variety of forms. This seemingly harmless build-up also accounts for 80 percent of all microbial infections. With chapters authored by experienced contributors from academia and industry, Applied Biomedical Microbiology: A Biofilms Approach demonstrates effective ways to combat the health and economic havoc that biofilms are wreaking, while also tapping into their positive potential. Replete with Tables and Illustrations, Many in ColorUnder the editorial guidance of esteemed industrial microbiologist Dr. Daryl Paulson, this book presents an in-depth discussion of medically challenging biofilms. It provides a solid foundation in the basic microbiology of biofilms and then goes on to discuss the biofilms associated with medical devices, catheters, and dental unit water lines as well as those that impact cardiovascular medicine, the gastrointestinal system, periodontal disease, and chronic wounds. This informative work concludes with an exploratory chapter of the various methods used to investigate biofilms. Applied Biomedical Microbiology: A Biofilms Approach presents key information clearly and concisely - a useful guide for environmental, food, and water microbiologists as well as biochemists, pharmaceutical scientists, and product and biofilm engineers.

Carefully designed for use by clinical and pharmaceutical researchers and scientists, Handbook of Regression Analysis and Modeling explores statistical methods that have been adapted into biological applications for the quickly evolving field of biostatistics. The author clearly delineates a six-step method for hypothesis testing using data that mimics real life. Relying heavily on computer software, he includes exploratory data analysis to evaluate the fit of the model to the actual data. The book presents a well-defined procedure for adding or subtracting independent variables to the model variable and covers how to apply statistical forecasting methods to the serially correlated data characteristically found in clinical and pharmaceutical settings. The stand alone chapters allow you to pick and choose which chapter to read first and home in on the information that fits your immediate needs. Each example is presented in computer software format. The author uses MINITAB in the book but supplies instructions for SAS and SPSSX, making the book easily adaptable to individual situations. Although written with the assumption that the reader has knowledge of basic and matrix algebra, the book supplies a short course on matrix algebra in the appendix for those who need it. Covering more than just statistical theory, the book provides advanced methods that you can put to immediate use.

A range of factors must be considered when developing a topical antimicrobial for use in a healthcare personnel handwash, surgical scrub, or preoperative skin preparation. Antimicrobial effectiveness, low skin irritation, ease of use, and pleasing aesthetics are all essential if the product is to succeed. In addition, all facets of the product must comply with stringent regulatory requirements. With updated protocols and research, Topical Antimicrobials Testing and Evaluation, Second Edition comprehensively presents and reviews the latest techniques for testing antimicrobial compounds for effectiveness and regulatory compliance. Topics include: The anatomical structure of the skin and skin microbiology relevant to product testing Use of antimicrobial products against specific microorganisms such as Staphylococcus and Streptococcus species Measurement of antimicrobial action of topical antimicrobials from experimental design, microbiological, biostatistical, and marketplace perspectives Various aspects of the topical antimicrobial products currently in common use in medical, food service, and consumer markets Statistical analysis and specific statistical designs for clinical trials Epistemological requirements in evaluating the effects of specific treatments Evaluation strategies and sample working protocols for hand and body soaps, food-handler antimicrobial products, and medical/healthcare industry antimicrobial products The book is designed to inform industry and academia on the requirements to get products approved by the FDA and to market while also providing critical insight on ways to best service expanding markets.

This "nuts and bolts" book provides a condensation of biostatistical methods that applied microbiology researchers need to perform data analyses. Based on the author 's more than two decades of applied research and teaching experience, it is presented in a straight-forward manner, applicable by practicing microbiologists with minimal backgrounds in mathematics. All methods rely only on the use of a basic hand-held calculator. The overriding goal of this book is to ground one 's microbiological expertise and experience in one 's research pursuits, using biostatistics not as a black box, but as a tool.

Many Vietnam veterans struggled upon returning to the United States. They wrestled with the psychic trauma of the war and felt isolated and out of place, rejected by their country. Author Daryl Paulson, a Vietnam vet, experienced the same feelings of displacement and despair. But he eventually understood that the Vietnam experience was an initiatory one, complete with a call to adventure, an initiation, and a return home with a new identity as a hero, a veteran. In "Walking the Point," Paulson's healing journey provides a wise example for veterans of Vietnam and other wars, as well as their loved ones.

Since 1990, U.S. Veterans' centers have treated more than 1.6 million PTSD-affected men and women, including an estimated 100,000 from the Gulf War and an untallied total from the Iraq and Afghanistan fronts. The number also includes World War II veterans, because PTSD does not fade easily. Sufferers may experience the traumatic events in flashbacks that may seem as real as when they first occurred. Using first hand accounts, the authors offer insights into the realities of PTSD and combat trauma, and how symptoms may pervade even the most mundane of daily activities and cause sufferers to experience withdrawal, depression, violence, rage, and even suicide. In a new epilogue, the authors offer data about treatments and resources that both PTSD sufferers and their families and friends will value.

Across history, the condition has been called "soldier's heart," "shell shock," or "combat fatigue." It is now increasingly common as our service men and women return from Iraq, Afghanistan, and other ongoing combat zones. Since 1990, Veterans' centers here have treated more than 1.6 million affected men and women, including an estimated 100,000 from the Gulf War and an untallied total from the Iraq front and fighting in Afghanistan. The number also includes some 35,000 World War II veterans, because PTSD does not fade easily. Regardless of the months, years, and even decades that have passed, the traumatic events can flash back as seemingly real as they were when they occurred.In Haunted by Combat Paulson and Krippner range across history and into current experiences and treatments for this haunting disorder. They take us into the minds of PTSD-affected veterans, as they struggle against the traumatic events lingering in their minds, sometimes exploding into violent behavior. The authors explain how and why PTSD develops--and how we can help service members take the steps to heal today.

Showcasing a discussion of the experimental process and a review of basic statistics, this volume provides methodologies to identify general data distribution, skewness, and outliers. It features a unique classification of the nonparametric analogs of their parametric counterparts according to the strength of the collected data. Applied Statistical Designs for the Researcher discusses three varieties of the Student t test, including a comparison of two different groups with different variances; two groups with the same variance; and a matched, paired group. It introduces the analysis of variance and Latin Square designs and presents screening approaches to comparing two factors and their interactions.

From the slippery covering on rocks in a stream, to the clogging slime in a bathtub drain, biofilms are present in everyday life in a variety of forms. This seemingly harmless build-up also accounts for 80 percent of all microbial infections. With chapters authored by experienced contributors from academia and industry, Applied Biomedical Microbiology: A Biofilms Approach demonstrates effective ways to combat the health and economic havoc that biofilms are wreaking, while also tapping into their positive potential. Replete with Tables and Illustrations, Many in Color Under the editorial guidance of esteemed industrial microbiologist Dr. Daryl Paulson, this book presents an in-depth discussion of medically challenging biofilms. It provides a solid foundation in the basic microbiology of biofilms and then goes on to discuss the biofilms associated with medical devices, catheters, and dental unit water lines as well as those that impact cardiovascular medicine, the gastrointestinal system, periodontal disease, and chronic wounds. This informative work concludes with an exploratory chapter of the various methods used to investigate biofilms. Applied Biomedical Microbiology: A Biofilms Approach presents key information clearly and concisely - a useful guide for environmental, food, and water microbiologists as well as biochemists, pharmaceutical scientists, and product and biofilm engineers.