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The goal of this work is summarize the contribution that
insertional mutagenesis has made to our understanding of cancer. A
variety of insertional mutagens are presented that have been used
to study a variety of tumor types in several model organisms. In
addition, the impact of insertional mutagenesis in several gene
therapy trials is discussed along with strategies to avoid such
complications in future clinical trials.
The goal of this work is summarize the contribution that
insertional mutagenesis has made to our understanding of cancer. A
variety of insertional mutagens are presented that have been used
to study a variety of tumor types in several model organisms. In
addition, the impact of insertional mutagenesis in several gene
therapy trials is discussed along with strategies to avoid such
complications in future clinical trials.
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