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Mass spectrometry underwent dramatic changes during the decade of
the 1980s. Fast atom bombardment (F AB) ionization, developed by
Barber and coworkers, made it possible for all mass spectrometry
laboratories to analyze polar, highly functionalized organic
molecules, and in some cases ionic, inorganic, and organometallic
compounds. The emphasis of much of this work was on molecular
weight determination. Parallel with the development of ionization
methods (molecular weight mass spectrometry) for polar biological
molecules, the increased mass range of sector and quadrupole mass
spectrometers and the development of new instruments for tandem
mass spectrometry fostered a new era in structural mass
spectrometry. It was during this same period that new instrument
technologies, such as Fourier transform ion cyclotron resonance,
radio frequency quadrupole ion trap, and new types of
time-of-flight mass spectrometers, began to emerge as useful
analytical instruments. In addi tion, laser methods useful for both
sample ionization and activation became commonplace in almost every
analytical mass spectrometry laboratory. In the last 5 years, there
has been explosive growth in the area of biological mass
spectrometry. Such ionization methods as electrospray and
matrix-assisted laser desorption ionization (MALDI) have opened new
frontiers for both molecular weight and structural mass
spectrometry, with mass spectrometry being used for analysis at the
picomole and even femto mole levels. In ideal cases, subfemtomole
sample levels can be successfully analyzed. Sample-handling methods
are now the limiting factor in analyz ing trace amounts of
biological samples.
The field of gas phase inorganic ion chemistry is relatively new;
the early studies date back approximately twenty years, but there
has been intense interest and development in the field in the last
ten years. As with much of modern chemistry, the growth in gas
phase inorganic ion chemistry can be traced to the development of
instrumentation and new experimental methods. Studies in this area
require sophisticated instruments and sample introduc tion/
ionization methods, and often these processes are complicated by
the need for state-selecting (or collisionally stabilizing) the
reactive species in order to assign the chemistry unequivocally. At
the present level of experimental development, a wide range of
experiments on diverse ionic systems are possible and many detailed
aspects of the chemistry can be studied. Gas Phase Inorganic
Chemistry focuses on the reactions of metal ions and metal
clusters, and on the study of these species using the available
modern spectroscopic methods. Three of the twelve chapters cover
the chemistry of ionic monometal transition metal ions and the
chemistry of these species with small diatomics and model organics.
Two of the chapters focus on the studies of the chemical and
physical properties of (primarily) transition metal clusters, and
these chapters review experimental methods and capabilities. Two
chapters also deal with the chemistry of transition metal carbonyl
clusters, and these chapters address issues important to cluster
growth and activation as well as the characterization of such
species."
Mass spectrometry underwent dramatic changes during the decade of
the 1980s. Fast atom bombardment (F AB) ionization, developed by
Barber and coworkers, made it possible for all mass spectrometry
laboratories to analyze polar, highly functionalized organic
molecules, and in some cases ionic, inorganic, and organometallic
compounds. The emphasis of much of this work was on molecular
weight determination. Parallel with the development of ionization
methods (molecular weight mass spectrometry) for polar biological
molecules, the increased mass range of sector and quadrupole mass
spectrometers and the development of new instruments for tandem
mass spectrometry fostered a new era in structural mass
spectrometry. It was during this same period that new instrument
technologies, such as Fourier transform ion cyclotron resonance,
radio frequency quadrupole ion trap, and new types of
time-of-flight mass spectrometers, began to emerge as useful
analytical instruments. In addi tion, laser methods useful for both
sample ionization and activation became commonplace in almost every
analytical mass spectrometry laboratory. In the last 5 years, there
has been explosive growth in the area of biological mass
spectrometry. Such ionization methods as electrospray and
matrix-assisted laser desorption ionization (MALDI) have opened new
frontiers for both molecular weight and structural mass
spectrometry, with mass spectrometry being used for analysis at the
picomole and even femto mole levels. In ideal cases, subfemtomole
sample levels can be successfully analyzed. Sample-handling methods
are now the limiting factor in analyz ing trace amounts of
biological samples."
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