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Lyme Borreliosis is a worldwide infectious disease causing a
multisystem illness with considerable morbidity, particularly in
North America and Europe. The causative agent is the spirochaete
Borrelia burgdorferi, which is usually transmitted by the ixodid
tick from animal reservoirs. This book is formed by contributions
from the Second European Symposium on Lyme Borreliosis, held at St
George's Hospital Medical School, London in 1993, which reviewed
the current state of knowledge of the condition with regard to
clinical manifestations, diagnosis, treatment, ecology,
epidemiology, biology and immunopathogenesis. In this book,
important data is reviewed concerning the clinical manifestations
of Lyme Borreliosis. It seems that strain variation of the
spirochaete is the main cause of regional differences seen in the
clinical presentation of patients. One striking example of this, is
the relatively high incidence of Lyme arthritis in the USA and
apparent rarity of this manifestion in some areas of Europe. These
important studies open the way for exciting new research that
focuses on the immunological and molecular mechanisms that result
in disease. A full insight into the ecology of Borrelia burgdorferi
is essential to a balanced understanding of the disease and a
number of excellent reviews on this subject are included.
Significant advances with regard to the biology of Borrelia
burgdorjeri and the immunopathogenic mechanisms that result in
disease have been made, enabling the role of the Band T lymphocytes
in disease to be established and the development of sophisticated
phenotyping methods, improved diagnostic tests and effective
vaccines.
Clinical Manifestations and Treatment: Clinical Manifestations of
Lyme Borreliosis in an Italian Endemic Region; G. Bianchi. Lyme
Borreliosis in Children; H.J. Christen, F. Hanefield. Ecology and
Epidemiology: Lyme Borreliosis in Australia; R.D. Barry, et al.
Geographic Diversity of Lyme Borreliosis; G. Bianchi. Role of Host
Density in the Ecology of Lyme Disease; T.E. Awerbuch, A. Spielman.
Biology of Immunopathogenesis: Expression of Public Idiotypes in
Patients with Lyme Arthritis; J.S. Axford, et al. Lyme Disease in
an Experimental Model; M.D. Gibson, et al. Chemotaxonomy of
Borrelia; M.A. Livesley, P.A. Nuttall. Diagnosis: Detection of Lyme
Disease Spirochaete DNA in Clinical Samples; K.J. Cann, et al.
Clinical and Serological Study of Lyme Borreliosis in a Population
of Neurological Patients; E. Capello. Pitfalls in the Laboratory
Diagnosis of Lyme Borreliosis; S.J. Cutler. 36 additional articles.
Index.
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