Statistical methods for clinical trials have been an area of active research in Biostatistics since the first modern clinical trials were mounted in 1946 by the British Medical Research Council in whooping cough and tuberculosis. Often, the participants in clinical trials suffer from potentially fatal chronic diseases, and it is especially important that these experiments in medical research use designs that are efficient, can be understood by physicians, policy makers and patients, respond quickly new ideas in medicine and statistics, and, perhaps above all, show respect for the complex and important ethical issues that arise in these settings. This book explores some recent thinking in designs for clinical trials, including alternative designs for phase I studies, interim monitoring for futility, adaptive designs based on accumulating outcome data, and designs of new, targeted therapies. The book is intended for both the statistical practitioner, who may be too busy to stay abreast of the literature on statistical methods, as well as statisticians conducting research in clinical trials.

Recognize and celebrate the magic of life with timeless rites and spells. Create a magical household--a haven of harmony, safety, spirituality, security, and romance. The benefits include a happier existence, protection against thieves, improved health, restful sleep, satisfying spiritual experiences, and a perfect environment for positive magic. This warm and wise guide by much loved author Scott Cunningham has been helping people create sacred space in their homes and gardens for nearly twenty years.

In the contemporary United States, there are hundreds of thousands of Protestant churches whose members habitually carry their Bibles with them. These churches - often referred to as evangelical or fundamentalist - play a crucial role in shaping American society. In this book, David Watt draws on years of fieldwork to present an elegant reinterpretation of the way that conservative Protestants influence American politics and culture. At the heart of the book is a sympathetic, but far from uncritical, analysis of those forms of social power that are assumed to be natural among Bible-carrying Christians. While outsiders often presuppose that evangelical Christians take for granted the authority of certain institutions (among them the American state, corporations, ministers, men, and heterosexuals), Watt argues that the reality is far more complex. This is a concise and lively book that sheds new light on the way that Bible-carrying Christians influence the way that people in America think - and avoid thinking - about social power.

This book will examine current issues and controversies in the design of clinical trials, including topics in adaptive and sequential designs, the design of correlative genomic studies, the design of studies in which missing data is anticipated. Each chapter will be written by an expert conducting research in the topic of that chapter. As a collection, the chapters would be intended to serve as a guidance for statisticians designing trials.

The period from 1830 to 1937 was transformative for modern Quakerism. Practitioners made significant contributions to world culture, from their heavy involvement in the abolitionist and women’s rights movements and creation of thriving communities of Friends in the Global South to the large-scale post–World War I humanitarian relief efforts of the American Friends Service Committee and Friends Service Council in Britain. The Creation of Modern Quaker Diversity, 1830–1937 explores these developments and the impact they had on the Quaker religion and on the broader world. Chapters examine the changes taking place within the denomination at the time, including separations, particularly in the United States, that resulted in the establishment of distinct branches, and a series of all-Quaker conferences in the early twentieth century that set the agenda for Quakerism. Written by the leading experts in the field, this engaging narrative and penetrating analysis is the authoritative account of this period of Quaker history. It will appeal to scholars and lay Quaker readers alike and is an essential volume for meeting libraries. In addition to the editors, the contributors include Joanna Clare Dales, Richard Kent Evans, Douglas Gwyn, Thomas D. Hamm, Robynne Rogers Healey, Julie L. Holcomb, Sylvester A. Johnson, Stephanie Midori Komashin, Emma Jones Lapsansky, Isaac Barnes May, Nicola Sleapwood, Carole Dale Spencer, and Randall L. Taylor.

Spell Crafts
Take a look at your hands. See them as wondrous vehicles of power. Feel the energy that flows through everything you do. Tap into that power Carve a symbol, dip a candle, mix fragrant herbs, sculpt clay, and make your life all that you want it to be. When crafts are used to create objects intended for ritual or to symbolize the divine, the connection between the craftsperson and divinity grows more intense.
This second edition of "Spell Crafts," the much-loved and oft-read guide to magical handwork, features new illustrations and a new preface by David Harrington. Learn how to create and use all of the following:
- magical simmering potpourris
- a beaded psychic mandala
- clay pentacles, plaques, and runic dice
- a shaman''s arrow
- sand paintings
- Corn Mother
- a magical spell broom
- protective hex sign
- Witch bottles
- flower garlands
- spell banner
- magic mirror
- prosperity trivet
- wheat weaving

David Harrington Watt's Antifundamentalism in Modern America gives us a pathbreaking account of the role that the fear of fundamentalism has played—and continues to play—in American culture. Fundamentalism has never been a neutral category of analysis, and Watt scrutinizes the various political purposes that the concept has been made to serve. In 1920, the conservative Baptist writer Curtis Lee Laws coined the word "fundamentalists." Watt examines the antifundamentalist polemics of Harry Emerson Fosdick, Talcott Parsons, Stanley Kramer, and Richard Hofstadter, which convinced many Americans that religious fundamentalists were almost by definition backward, intolerant, and anti-intellectual and that fundamentalism was a dangerous form of religion that had no legitimate place in the modern world. For almost fifty years, the concept of fundamentalism was linked almost exclusively to Protestant Christians. The overthrow of the Shah of Iran and the establishment of an Islamic republic led to a more elastic understanding of the nature of fundamentalism. In the late 1970s and early 1980s, Americans became accustomed to using fundamentalism as a way of talking about Muslims, Jews, Hindus, Sikhs, and Buddhists, as well as Christians. Many Americans came to see Protestant fundamentalism as an expression of a larger phenomenon that was wreaking havoc all over the world. Antifundamentalism in Modern America is the first book to provide an overview of the way that the fear of fundamentalism has shaped U.S. culture, and it will lead readers to rethink their understanding of what fundamentalism is and what it does.