In this issue of Otolaryngologic Clinics, guest editors Drs. Devyani Lal, Angela Donaldson, and David Jang bring their considerable expertise to the topic of Unified Airway Disease. Unified airway disease is a recently defined entity that alludes to inflammation disease processes that involve both upper and lower airway, and co-management of these conditions by otolaryngologists and allergy immunologists often result in improved outcomes. In this issue, experts in the field provide a thorough overview of the pathophysiology, diagnosis, and management of unified airway disease through the perspective of an otolaryngologist co-managing the patient with an allergy-immunology colleague. Contains 16 practice-oriented topics including environmental factors; eosinophilic disease; non-eosinophilic and granulomatous disease; cystic fibrosis; pediatric unified airway disease; unified airway disease medical and surgical management; future directions; and more. Provides in-depth clinical reviews on unified airway disease, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.