The first season of the drama series starring Jeremy Irons as Rodrigo Borgia, the head of the powerful family that dominated Italy in the Renaissance. When the Borgia family use their influence to gain Rodrigo, the rising power within the family, the position of Pope, perhaps even they are unprepared for the manner in which their relative will abuse his position. As Pope Alexander VI, Rodrigo sets about using his power to ruthlessly increase the family's wealth and status, while committing almost every sin imaginable. François Arnaud, Holliday Grainger and Lotte Verbeek co-star.

This book commemorates the scientific contributions of distinguished statistician, Andrei Yakovlev. It reflects upon Dr. Yakovlev's many research interests including stochastic modeling and the analysis of micro-array data, and throughout the book it emphasizes applications of the theory in biology, medicine and public health. The contributions to this volume are divided into two parts. Part A consists of original research articles, which can be roughly grouped into four thematic areas: (i) branching processes, especially as models for cell kinetics, (ii) multiple testing issues as they arise in the analysis of biologic data, (iii) applications of mathematical models and of new inferential techniques in epidemiology, and (iv) contributions to statistical methodology, with an emphasis on the modeling and analysis of survival time data. Part B consists of methodological research reported as a short communication, ending with some personal reflections on research fields associated with Andrei and on his approach to science. The Appendix contains an abbreviated vitae and a list of Andrei's publications, complete as far as we know. The contributions in this book are written by Dr. Yakovlev's collaborators and notable statisticians including former presidents of the Institute of Mathematical Statistics and of the Statistics Section of the AAAS. Dr. Yakovlev's research appeared in four books and almost 200 scientific papers, in mathematics, statistics, biomathematics and biology journals. Ultimately this book offers a tribute to Dr. Yakovlev's work and recognizes the legacy of his contributions in the biostatistics community.

The writers of Gothic literature reflect in their works the concerns and fears of the times in which they were created. These fears, in turn, destabilize the reader; that is, they create within the reader a sense of uneasiness characteristic of the Gothic genre, an uneasiness that comes from the challenging of social and cultural conventions or cherished beliefs. In doing so, these works are also cultural artifacts, for they reflect issues central to society at a given point in time. This book examines the process of destabilization in the modern American Gothic. The volume focuses on the works of three popular 20th-century Gothic writers: H.P. Lovecraft, Richard Matheson, and Stephen King. It argues that science and technology are central to the destabilization process in works by these authors, and it demonstrates how, as cultural artifacts, their writings reflect the fears and concerns of contemporary society. Thus the volume demonstrates how the works of these authors remain within the Gothic literary tradition, while they simultaneously adapt that tradition for a modern audience.

This book provides an accessible but rigorous introduction to asymptotic theory in parametric statistical models. Asymptotic results for estimation and testing are derived using the “moving alternative� formulation due to R. A. Fisher and L. Le Cam. Later chapters include discussions of linear rank statistics and of chi-squared tests for contingency table analysis, including situations where parameters are estimated from the complete ungrouped data. The book is based on lecture notes prepared by the first author, subsequently edited, expanded and updated by the second author. Features Succinct account of the concept of ``asymptotic linearity� and its uses Simplified derivations of the major results, under an assumption of joint asymptotic normality Inclusion of numerical illustrations, practical examples and advice Highlighting of some unexpected consequences of the theory Large number of exercises, many with hints to solutions Some facility with linear algebra and with real analysis including “epsilon-delta� arguments is required. Concepts and results from measure theory are explained when used. Familiarity with undergraduate probability and statistics including basic concepts of estimation and hypothesis testing is necessary, and experience with applying these concepts to data analysis would be very helpful.

This book commemorates the scientific contributions of distinguished statistician, Andrei Yakovlev. It reflects upon Dr. Yakovlev's many research interests including stochastic modeling and the analysis of micro-array data, and throughout the book it emphasizes applications of the theory in biology, medicine and public health. The contributions to this volume are divided into two parts. Part A consists of original research articles, which can be roughly grouped into four thematic areas: (i) branching processes, especially as models for cell kinetics, (ii) multiple testing issues as they arise in the analysis of biologic data, (iii) applications of mathematical models and of new inferential techniques in epidemiology, and (iv) contributions to statistical methodology, with an emphasis on the modeling and analysis of survival time data. Part B consists of methodological research reported as a short communication, ending with some personal reflections on research fields associated with Andrei and on his approach to science. The Appendix contains an abbreviated vitae and a list of Andrei's publications, complete as far as we know. The contributions in this book are written by Dr. Yakovlev's collaborators and notable statisticians including former presidents of the Institute of Mathematical Statistics and of the Statistics Section of the AAAS. Dr. Yakovlev's research appeared in four books and almost 200 scientific papers, in mathematics, statistics, biomathematics and biology journals. Ultimately this book offers a tribute to Dr. Yakovlev's work and recognizes the legacy of his contributions in the biostatistics community.