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This book is based on presentations given at CGRP '98, the Third
International Meeting on CGRP and related peptides held in the UK
in May 1998. The principal speakers have each contributed a chapter
and many of the short and poster communications will also be found
here. This book follows from the tradition set by the First and
Second Meetings in 1992 and 1995 when the proceedings were
published. The work is aimed at the specialist in the field, but it
is hoped that many of the chapters will also prove useful as
introductions to those wishing to gain greater familiarity with the
biology and pharmacology of these important peptides. The book
begins with a broad overview of the field, past and present. It is
followed by two chapters dealing with the "classical" pharmacology
of CGRP. In particular there is an account of the pitfalls of the
present generation of CGRP antagonists and the dangers of assuming
that every action of CGRP is mediated by a CGRP receptor. However
the bulk of this section is taken up by the recent developments
concerning the cloning of receptors for CGRP and adrenomedullin. An
exciting story is emerging of how a single molecule, calcitonin
receptor-like receptor (CRLR), can mediate the response to both
CGRP and adrenomedullin depending on the presence of different
members of a family of accessory proteins, the Receptor Activity
Modifying Proteins (RAMPs). This is covered in three chapters and
is followed by an account of another accessory protein associated
with CGRP responsiveness, Receptor Component Protein (RCP).
Following sections of the book deal with the biochemistry,
physiology and pharmacology of receptors for the allied peptides
amylin and adrenomedullin. The close connections between amylin and
calcitonin receptors are highlighted and role of amylin in the
regulation of food intake is then considered. The molecular nature
of adrenomedullin receptors is addressed in an earlier chapter but
in this section their pharmacology is examined. T
This book is based on presentations given at CGRP '98, the Third
International Meeting on CGRP and related peptides held in the UK
in May 1998. The principal speakers have each contributed a chapter
and many of the short and poster communications will also be found
here. This book follows from the tradition set by the First and
Second Meetings in 1992 and 1995 when the proceedings were
published. The work is aimed at the specialist in the field, but it
is hoped that many of the chapters will also prove useful as
introductions to those wishing to gain greater familiarity with the
biology and pharmacology of these important peptides. The book
begins with a broad overview of the field, past and present. It is
followed by two chapters dealing with the "classical" pharmacology
of CGRP. In particular there is an account of the pitfalls of the
present generation of CGRP antagonists and the dangers of assuming
that every action of CGRP is mediated by a CGRP receptor. However
the bulk of this section is taken up by the recent developments
concerning the cloning of receptors for CGRP and adrenomedullin. An
exciting story is emerging of how a single molecule, calcitonin
receptor-like receptor (CRLR), can mediate the response to both
CGRP and adrenomedullin depending on the presence of different
members of a family of accessory proteins, the Receptor Activity
Modifying Proteins (RAMPs). This is covered in three chapters and
is followed by an account of another accessory protein associated
with CGRP responsiveness, Receptor Component Protein (RCP).
Following sections of the book deal with the biochemistry,
physiology and pharmacology of receptors for the allied peptides
amylin and adrenomedullin. The close connections between amylin and
calcitonin receptors are highlighted and role of amylin in the
regulation of food intake is then considered. The molecular nature
of adrenomedullin receptors is addressed in an earlier chapter but
in this section their pharmacology is examined. The pathophysiology
of CGRP and related peptides formed a significant part of the
meeting. Three chapters examine the role of CGRP in vascular
disorders, joint dysfunction and gastrointestinal pathology. A
separate section considers the role of CGRP in headache and
migraine. The book concludes with a selection of the short oral and
poster communications and then an important appendix, reflecting a
workshop held to discuss the nomenclature of CGRP, amylin and
adrenomedullin receptors. As the majority of the active workers in
the field were present at this meeting it is hoped that the
consensus view presented here might be widely acceptable.
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