Motor System Disorders, Volume 196, Part Two, Spinal Cord, Neurodegenerative, and Cerebral Disorders and Treatment provides a comprehensive review of research and best practice clinical management of spinal cord, neurodegenerative, and cerebral disorders. Encompassing hereditary and acquired disorders from disease and accident, the book explores motor control disorders associated with stroke, dementia, seizure, encephalitis, and more. Covering disorders of both children and adults, the book discusses the latest advances in treatments related to neuroplasticity, neural tissue transplantation, and immunotherapy.

This issue of Neurologic Clinics, guest edited by Dr. David S. Younger, covers Vasculitis and the Nervous System. Topics include, but are not limited to, History and Background of Vasculitis, Overview of Primary and Secondary Vasculitis, Epidemiology of Primary Systemic Vasculitis, Comorbidity and Health Outcomes of Vasculitis, Experimental Autoimmune Vasculitis, Genetic Basis of Vasculitides, General Approach to the Patient with Vasculitis, ANCA-Associated Vasculitis, Polyarteritis Nodosa, Giant Cell Arteritis, Dermatologic Aspects of Vasculitides, Neuro-Ophthalmologic Aspects of Vasculitides, The Blood-Brain Barrier: Implications for Vasculitis, Adult Primary Angiitis of the Central Nervous System, Childhood Inflammatory Brain Diseases, Adult Vasculitic Stroke, Central Nervous System Vasculitis Due to Substance Abuse, Peripheral Nerve Vasculitis: Classification and Disease Associations, Hashimoto Encephalopathy: Autoimmune Encephalitis or Vasculitis, and Treatment of Primary Systemic and Nervous System Vasculitis.

Motor System Disorders, Volume 195, Part One, Normal Physiology and Function and Neuromuscular Disorders summarizes recent advances and best practice for understanding normal physiology and function of the larger motor system as well as the diagnosis, course, and treatment of neuromuscular disorders. The work includes neuroanatomy, circuits, and synapses, and discusses how different parts of the brain contribute to motor control, including both vestibular and cerebellar motor control, as well as the influences of the parietal and frontal lobes. Diagnostic methods include genetic evaluation, electrodiagnosis, pathology, and brain imaging. Neuromuscular disorders of both children and adults are included.

This issue of Neurologic Clinics, edited by Dr. David Younger, is focused on Global and Domestic Public Health and Neuroepidemeiology. Topics covered in the issue include, but are not limited to research methods; gene-environment interplay; Alzheimer disease; headache disorders; multiple sclerosis and related disorders; lyme neuroborreliosis; cerebrovascular disease; neuro-oncology; community health needs assessment; and neurologic public health in the BRICS.

There are millions of people who experience issues related to brain health--depression, attention issues, anxiety, forgetfulness, fatigue, and even chronic pain--yet can’t figure out what’s causing their problems and can’t find any relief. They may have seen a myriad of doctors, many of whom do not take their complaints seriously, or worse, turn to the easy, albeit inappropriate fix of antidepressants or antianxiety medications. Traditional medications, supplements, or other therapies haven’t worked. No matter what their age—from children to teens to seniors--these people and their loved ones are frustrated, scared, and confused by their continued poor health. Countless others display more severe psychiatric symptoms that seem to come out of nowhere: obsessive-compulsive behaviors, suicidal thoughts, tics, and mood swings reminiscent of bipolar disorder. Sometimes, the person affected is the only one that notices a change to the way they think or feel, and they suffer in silence. Or, they reach out to try to get help, and are all too frequently misdiagnosed. Now, David Younger, a world-renowned physician, board-certified in Internal Medicine, Neurology and Psychiatry, with postdoctoral training in public health and epidemiology, can finally provide relief to these patients and their families. His diagnostic techniques and treatment protocols will help readers identify the true cause of their symptoms and put them on a clear path to healing so they no longer feel crazy, out of control, forgetful, and exhausted. THE AUTOIMMUNE BRAIN connects common brain health symptoms to the changes in the immune system, and particularly bacterial, viral, and parasitic infections. In this book, Younger will explain his groundbreaking research and adds a new component: how traumatic stress (whether physical or emotional) and genetics affects this same triad as inextricable factors in initiating disease and brain health symptoms. In fact, a change in personality, behavior, coping style, and one’s emotional state may be the first clue that there is a health problem brewing somewhere else in the body. Readers will find new answers to troubling conditions, including: · Alzheimer’s disease · Anxiety · Arthritis · Autism · Bacterial infections · Bipolar Disorder · Cancer · Celiac disease and gluten intolerances · Chronic Fatigue Syndrome (now referred to as Systemic Exertion Intolerance Disease) · Chronic Pain · Dementia · Depression · Endocrine Disorders · Lyme disease and co-infections · Obsessive Compulsive Disorder · Porphyria · Post-Traumatic Stress Disorder A 5-Step Plan for Optimal Brain and Body Health Younger has focused his career on neuroimmunology--the intersection of neurology and how the immune system affects the brain. He was among the first to bring to the nation’s awareness the triad of infection, immunity, and inflammation, abbreviated as “I-Cubed,” and known more commonly by physicians as post-infectious autoimmunity. More importantly, Younger has developed cutting edge treatment protocols centered on immune modulatory therapy (known as IVIg) that have been adopted by doctors across the country and will be featured in this book. His unique treatment plan has become the most widely employed immune modulating agent for autoimmune neurological disorders. Including the most recent research and illuminating patient anecdotes, this new book highlights an early detection and treatment model that is based on a simple 5-step plan that can help readers of all ages reverse their brain health issues as well as their physical health by resetting the immune system. This will be the first book to explain to a lay audience in clear and accessible language, how seemingly unrelated diseases are linked to a common cause-- autoimmunity--and can be treated by following a singular immune-enhancing program that addresses brain health. While our genetic blueprint presumably maps an unchangeable path to illnesses, epigenetics shows that the genes for a variety of inflammatory autoimmune and neurodegenerative disorders may be silenced by following this holistic approach. Much like high blood pressure, obesity, and other persistent illnesses, autoimmunity needs to be managed daily with an individualized program that works. This book will present Younger’s new paradigm for identifying illness and resetting the immune system, summarized by the acronym TAPES: · Test for the most likely autoimmune disturbance right at home, and discover how a specific autoimmune response may be affecting brain health · Apply immune modulating therapies (under a doctor’s care) that will address both the immune response and changes to brain health · Participate in the most effective behavioral/therapeutic options to reduce stress and reverse fatigue, anxiety, depression, and memory loss · Eat & Exercise to restore brain health, alleviate pain, and enhance the immune system · Survey your home for chemical exposures, and remove mold, heavy metals, and other allergens that can stand in the way of a full recovery Tests The finished book will feature three unique tests readers can rely on to help diagnose an autoimmune brain health issue. The first test will clearly show how an underlying illness may in cause brain health symptoms including fatigue, forgetfulness, anxiety, depression, poor attention, loss of memory, and more. Created specifically for this book, these tests are the best and least invasive ways for readers to figure out and manage their symptoms: the results will direct them to the appropriate chapters in the book for specific treatments.

There are millions of people who experience issues related to brain health-depression, attention issues, anxiety, forgetfulness, fatigue, and even chronic pain-yet can't figure out what's causing their problems and can't find any relief. They may have seen a myriad of doctors, many of whom do not take their complaints seriously, or worse, turn to the easy, often inappropriate fix of antidepressants or anti-anxiety medications. Traditional medications, supplements, or other therapies haven't worked. No matter what their age-from children to teens or seniors-people and their loved ones are frustrated, scared, and confused by their continued poor health. Countless others display severe psychiatric symptoms that seem to come out of nowhere, ranging from tics, obsessive-compulsive behaviors and anxiety, to depression, bipolar-like mood swings, and even borderline personality disorder and suicidal ideas. Sometimes, the people affected are the only ones that notices a change to the way they think or feel, and they suffer in silence. Or, they reach out to try to get help, and are all too frequently misdiagnosed. David Younger, a world-renowned physician, provides relief to these patients and their families. His diagnostic techniques and treatment protocols will help readers identify the true cause of their symptoms and put them on a clear path to healing so they no longer feel unbalanced, out of control, forgetful, and exhausted. The Autoimmune Brain connects common brain health symptoms to the changes in the immune system, and particularly bacterial, viral, and parasitic infections. Younger explains his groundbreaking research and adds a new component: how traumatic stress (whether physical or emotional) and genetics affects this same triad as inextricable factors in initiating disease and brain health symptoms. In fact, a change in personality, behavior, coping style, and one's emotional state may be the first clue that there is a health problem brewing somewhere else in the body. Readers will find new answers to troubling conditions, including: Alzheimer's disease; Anxiety; Arthritis; Autism; Autonomic disturbances; Bacterial and viral infections; Bipolar Disorder; Cancer; Celiac disease and gluten intolerances; Chronic Fatigue Syndrome (now referred to as Systemic Exertion Intolerance Disease); Chronic Pain; Dementia; Depression; Endocrine Disorders; Immune modulatory therapy using IVIg; Lyme disease and co-infections; Mast cell activation syndrome; Medical cannabis; Obsessive Compulsive Disorder; Orthostatic hypotension; Peripheral Neuropathy; Porphyria; Post-Traumatic Stress Disorder; and Postural orthostatic tachycardia.