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Why another series on infectious disease? The question is a fair
one in view of the proliferation of monographs, texts, and
periodicals on the vast subject of infectious disease. The goal of
this series is to provide an additional service to the clinician in
the form of clinical information not usually assembled in one
convenient volume. One type of monograph presented in this series
will cover a specific infection, detailing microbiologic, research
and clinical aspects. It is hoped that such a compilation will be
helpful in both its thoroughness and breadth to the clinician
interested in this particular problem. The other type of monograph
that this series will provide will discuss a clinical presentation
that comprises many possible specific etiologies. Volumes in the
series will be multiauthored, giving us the opportunity to invite
authorities in each specific area to contribute their expertise and
experience. Regular revisions are planned so that each volume will
remain as current as it is thorough. We hope that our goals are met
and that the present series of mono graphs establishes its own
identifiable and valuable niche in the growing compendium of
resource material available to the clinician. Preface to the Second
Edition Since the first edition of Infectious Mononucleosis was
published, we have seen exciting advances in our understanding of
this disease."
Dr. David Schlossberg presents his fifth volume in the series
Clinical Topics in Infectious Disease, Infections of the Nervous
System. This edited monograph brings together the leading
authorities in infectious disease, neurology, and radiology to
review the diagnosis and treatment of all major neurological
infections. Topics covered include meningitis; acute CNS
inflammation; infections of CNS shunts; brain and spinal epidural
abscesses; the cerebellum and CNS infection; post-infection
complications and syndromes; acute viral encephalitis;
neurodegenerative peripheral nerve diseases; myelitis; CNS
tuberculosis; cryptococcal, fungal, and parasitic infections;
neurosyphilis, AIDS; Lyme disease; diagnostic imaging of CNS
infection and inflammation; and evaluation of spinal fluid.
The gratifYing response to the first edition of Tuberculosis has
prompted this revision. There are many important changes
incorporated into this edition, including the dramatic effect of
AIDS on the incidence and clinical mani festations of mycobacterial
infection, new developments in epidemiology and bacteriology, and
thoroughly updated therapeutic recommendations and principles of
prophylaxis. The chapters that deal with clinical manifestations of
tuberculosis have also been updated and include important and
clinically applicable information on manifestations of tuberculosis
in both the normal and immunocomprom ised host. As with the first
edition, it is hoped that this text will continue to represent a
definitive resource for both the basic scientist and the clinician
who deal with the prevention and treatment of mycobacterial
infection. II Preface to the First Edition We have just witnessed
the lOOth anniversary of Koch's discovery of the tubercle bacillus.
This event did not end the centuries-long saga of tuber culosis,
however; it was but one major step in the ongoing struggle to un
derstand and combat this disease. Tuberculosis is very much with us
today, and its clinical manifestations and principles of treatment
must be understood by both the primary care physician and the
specialist. This monograph covers all aspects of tuberculosis in a
single volume. It is divided into three parts, covering,
respectively, general considerations, clin ical manifestations, and
atypical mycobacterial infection."
Infections of Leisure provides a thorough yet concise examination
of the infectious risks and diseases of leisure time activity.
Encompassing a wide range of medical and social interests, chapters
provide practical, clinical guidelines for the diagnosis and
management of various infectious risks in the garden, at the shore,
on fresh water, on camping trips, traveling abroad, and on the
farm. Additional chapters include up-to-date information on
foodborne illnesses, and on animal-associated infections, with
particular attention given to housepets. The rising prevalence of
Lyme Disease, hepatitis and food poisoning make this volume vitally
important. Family practitioners, internists, infectious disease
specialists, pediatricians, and emergency room physicians will all
benefit from the indispensable and practical information presented
in this unique, groundbreaking volume.
Why anDther series .on infectiDus disease? The questiDn is a fair
.one in view .of the proliferatiDn .of mDnDgraphs, texts, and
periDdicals .on the vast subject .of infectiDus disease. The gDal
.of this series is tD provide an additiDnal service tD the
clinician in the fDrm .of clinical infDrmatiDn nDt usually
assembled in .one convenient vDlume. One type .of mDnDgraph
presented in this series will CDver a specific infecti.on,
detailing microbi.ol.ogic research and clinical aspects. It is
h.oped that such a cDmpilati.on will be helpful in bDth its
thDroughness and breadth tD the clinician interested in this
particular problem. The .other type .of mDnDgraph that this series
will pr.ovide will discuss a clinical presentati.on that c.omprises
many pDssible specific etiDI.ogies. V.olumes in the series will be
multiauthDred, giving us the DppDrtunity tD invite auth.orities in
each specific area t.o cDntribute their expertise and experience.
Regular revisions are planned SD that each v.olume will remain as
current as it is thorDugh. We hDpe that .our gDals are met and that
the present series .of mDn.o graphs establishes its .own
identifiable and valuable niche in the growing cDmpendium .of
resDurce material available tD the clinician. Contents Series
Preface ....................................................... VB
Contributors
.......................................................... Xl
Introduction
......................................................... xv 1.
Acute Osteomyelitis FRANCIS A. WALDVOGEL
...................................... ."
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