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This issue will focus on the global state of hematology and will
include articles such as: The Global Burden of Anemia, Iron
Deficiency Anemia: Problems in Diagnosis and Therapy, Progress
Towards the Control and Management of the Thalassemias, Problems
and Approaches for Blood Transfusion in the Developing Countries,
and many more!
Hemoglobin is an iron-containing protein in red blood cells that
transports oxygen to tissues throughout the body. The abundance,
stability, and oxygen-carrying properties of hemoglobin can be
altered by genetic mutations. More than 1000 hemoglobin disorders
are known; hemoglobinopathies (e.g., sickle cell disease) and
thalassemias are some of the most common human genetic diseases
worldwide. Written and edited by experts in the field, this
collection from Cold Srping Harbor Perspectives in Biology covers
all aspects of hemoglobin and its diseases. Contributors examine
the structure, expression, and evolution of the globin genes, the
assembly of globin subunits into functional forms of hemoglobin,
and the numerous variants that result from genetic alterations. The
pathophysiological consequences of hemoglobin disorders (e.g.,
ineffective erythropoiesis and aberrant iron homeostasis), their
clinical manifestations, and epidemiological trends are also
described. This book includes discussions of management and
treatment strategies for hemoglobin disorders, such as
transfusions, iron- chelating agents, gene therapy, and stem cell
transplantation. It is an indispensable reference for biochemists,
geneticists, cell and developmental biologists, physiologists, and
all who are interested in reducing the medical burden of these
common genetic diseases.
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