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In the present work, floating microspheres of AZH were formulated
to provide site specific delivery of drug with a view to providing
an effective and safe therapy for eradication of H.pylori with a
reduced dose and reduced duration of therapy. The developed
floating microspheres of AZH have excellent buoyant ability, high
encapsulation and good release pattern. The slow but complete drug
release in the stomach is expected to increase bioavailability of
the drug as well its complete utilization which may results to
lower dose and GI side effects. It can be concluded that optimized
multi-unit floating AZH microspheres floating more than 8 hrs in
stomach. The floating microsphere is a potential system for
delivery of AZH in the stomach. So it is expected to provide
clinicians with a new choice of an economical, safe and low dose
formulation in the management of eradication of H.pylori.
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