A number of chronic respiratory diseases including chronic bronchitis, asthma, cystic fibrosis and bronchiectasis are characterized by mucus hypersecretion. Following damage to the airway epithelium, a repair process of dedifferentiation, regenerative proliferation and redifferentiation takes place that is invariably accompanied by mucus hypersecretion as a key element in the host defence mechanism. In chronic respiratory diseases, however, excessive mucus production leads to a pathological state with increased risk of infection, hospitalization and morbidity. An understanding of the mechanisms that underlie and maintain this hypersecretory phenotype is therefore crucial for the development of rational approaches to therapy.

Despite a high and increasing prevalence and cost to healthcare services and society, mucus hypersecretion in chronic respiratory disease has received little attention until recently, probably because of the difficulties inherent in studying this pathology. Only in the last few years have some of the genes involved in mucus secretion been characterized. The recent availability of genomic sequence information and specific antibodies has led to an explosion of interest in this area making this publication particularly timely.

This book draws together contributions from an international and interdisciplinary group of experts, whose work is focused on both basic and clinical aspects of the problem. Coverage includes epidemiology, airways infection and mucus hypersecretion, the genetics and regulation of mucus production, models of mucus hypersecretion, and the implications of new knowledge for the development of novel therapies.

Social and medical developments during the past century have led to a dramatic increase in life expectancy and hence populations in countries of the developed world in which up to half of adults are in the age range of 60-100. This has encouraged the study of organismic changes associated with healthy ageing, of which an early example is the erosion of homeostatic capabilities in multiple endocrine systems.

This book reviews and discusses the most recent advances in the understanding of the endocrine facets of ageing, drawing together findings from both basic and clinical research. The questions addressed include the following: what are the relative magnitudes and time courses of different endocrine adaptations in the ageing human and experimental animal? How do external factors influence the rates of progression of endocrine sequelae of ageing? What mechanisms underlie the disarray of endocrine axes in ageing? And what are the implications of therapeutic reconstitution with hormones in ageing? By bringing together an international and interdisciplinary group of experts, the book reviews much new and exciting work in this area and serves to identify promising new research directions.