This book is the first text to provide a comprehensive assessment of the application of fundamental principles of dissolution and drug release testing to poorly soluble compounds and formulations. Such drug products are, vis-a-vis their physical and chemical properties, inherently incompatible with aqueous dissolution. However, dissolution methods are required for product development and selection, as well as for the fulfillment of regulatory obligations with respect to biopharmaceutical assessment and product quality understanding. The percentage of poorly soluble drugs, defined in classes 2 and 4 of the Biopharmaceutics Classification System (BCS), has significantly increased in the modern pharmaceutical development pipeline. This book provides a thorough exposition of general method development strategies for such drugs, including instrumentation and media selection, the use of compendial and non-compendial techniques in product development, and phase-appropriate approaches to dissolution development. Emerging topics in the field of dissolution are also discussed, including biorelevant and biphasic dissolution, the use on enzymes in dissolution testing, dissolution of suspensions, and drug release of non-oral products. Of particular interest to the industrial pharmaceutical professional, a brief overview of the formulation and solubilization techniques employed in the development of BCS class 2 and 4 drugs to overcome solubility challenges is provided and is complemented by a collection of chapters that survey the approaches and considerations in developing dissolution methodologies for enabling drug delivery technologies, including nanosuspensions, lipid-based formulations, and stabilized amorphous drug formulations.

IT IS NOT JUST A GAME OF BASKETBALL When you get to know someone, it really takes a long time. But when you get to know and understand a race of people, it could take a lifetime

Jermaine's life appears to be the picture of perfection to the thousands of people who tune in to him and flock to his self-help seminars. Yet beneath it all, Jermaine is depressed and unhappy and lives his life in the exact opposite manner from which he preaches. After a failed attempt to commit suicide, Jermaine is hospitalized and has a revelation through an unlikely mentor. Jermaine realises that faith and a personal relationship with God were the missing pieces of his puzzling life

Sandy beaches represent some of the most dynamic environments on Earth and examining their morphodynamic behaviour over different temporal and spatial scales is challenging, relying on multidisciplinary approaches and techniques. Sandy Beach Morphodynamics brings together the latest research on beach systems and their morphodynamics and the ways in which they are studied in 29 chapters that review the full spectrum of beach morphodynamics. The chapters are written by leading experts in the field and provide introductory level understanding of physical processes and resulting landforms, along with more advanced discussions.

After Chance Howard, the man they call Brother Word, lays his healing hands on the sick he seems to the townspeople to disappear. But actually he is running - not only from the curious and the sceptics - but from his own pain. Two years earlier, though her faith that God would heal her through her husband never waned, Chance's beautiful young wife died from a painful illness. Blaming himself because his gift couldn't help her left Chance racked with guilt, remorse and doubt. After the old pastor recovers, Chance breaks his own rule, stays and lays hands on three others. One of them, a child, is the nephew of a newspaper reporter hungry for a career saving story. The other is a young female minister who bears an uncanny resemblance to his dead wife. Each of them, for their own reasons, decide they must discover who Chance really is and whether his gift is truly from God.