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A cutting-edge review of the latest findings on the complexities of
platelet function and the various means of inhibiting platelet clot
formation. The authors delineate an up-to-date picture of platelet
biology and describe methods for assessing platelet function,
including the commonly used platelet aggregation, thromboxane
production, procoagulant function, platelet function under flow,
and the expression of platelet activation markers. The focus is
both on the technology and the outcome of research on platelets,
including the fast developing fields of proteomics and genomics and
their application to platelet research. The clinical applications
of the various methods for the assessment of platelet function in
vivo, as well as antiplatelet therapy, are fully discussed.
A cutting-edge review of the latest findings on the complexities of
platelet function and the various means of inhibiting platelet clot
formation. The authors delineate an up-to-date picture of platelet
biology and describe methods for assessing platelet function,
including the commonly used platelet aggregation, thromboxane
production, procoagulant function, platelet function under flow,
and the expression of platelet activation markers. The focus is
both on the technology and the outcome of research on platelets,
including the fast developing fields of proteomics and genomics and
their application to platelet research. The clinical applications
of the various methods for the assessment of platelet function in
vivo, as well as antiplatelet therapy, are fully discussed.
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