There are 41 chapters in the manual under different section heads dealing with physiology, clinical applications, use in different types of respiratory failure, including end of life situations, and limitations, challenges as well as its use in pediatrics. This flagship book of ISCCM one of the first of its kind in India. Covers all aspects of noninvasive ventilation from initiation to disease specific conditions. Evidence-based and updated protocols have been used in easy to read format with flowcharts and diagrams. Stalwarts in this field have contributed to this book. This book will be helpful to all postgraduates, intensivists and physicians.