Molecular Nutrition and Diabetes: A Volume in the Molecular Nutrition Series focuses on diabetes as a nutritional problem and its important metabolic consequences. Fuel metabolism and dietary supply all influence the outcome of diabetes, but understanding the pathogenesis of the diabetic process is a prelude to better nutritional control. Part One of the book provides general coverage of nutrition and diabetes in terms of dietary patterns, insulin resistance, and the glucose-insulin axis, while Part Two presents the molecular biology of diabetes and focuses on areas such as oxidative stress, mitochondrial function, insulin resistance, high-fat diets, nutriceuticals, and lipid accumulation. Final sections explore the genetic machinery behind diabetes and diabetic metabolism, including signaling pathways, gene expression, genome-wide association studies, and specific gene expression. While the main focus of each chapter is the basic and clinical research on diabetes as a nutritional problem, all chapters also end with a translational section on the implications for the nutritional control of diabetes.

Chronic Complications of Diabetes Mellitus: Current Outlook and Novel Pathophysiological Insights provides a holistic view of the disease, discussing not only its classical complications but also the under recognized and managed conditions associated with diabetes. Chapters also discuss advances in our understanding of the genomic architecture of diabetes complications and how precision medicine can be used to personalize their management. Endocrinologists, diabetologists, primary care physicians and researchers interested in complications of diabetes mellitus and cutting-edge information will find this to be a comprehensive tome on the topic. Diabetes complications include pathological changes usually related to the vascular system and classical target organs. However, there are also nonclassical complications independent or partially independent from vascular damage that are often overlooked.

Designers of technology have a major responsibility in the current age. Their designs can have tremendous effects on society, in both the short and the long term. In fact, sustainable development itself has all the characteristics of a design project, albeit a vast one. But a failed product design here will be not just be unsuccessful in the market - it will have far-reaching consequences. It is our common responsibility to make the project successful. Technology has played an important role in creating the problems that we now face; but it will also play an important role in solving them. But this does not mean the technological fix will be easy. How do we allocate resources and attention when there are myriad issues under the umbrella of "sustainable development" currently in competition with one another? How do we arrive at precise specifications for the sustainable technologies that are to be developed and, furthermore, reach consensus on these specifications? What if our sustainable technological solutions aggravate other problems or create new ones? And, because sustainable development is all about the long-term consequences of our actions, how do we assess the effects of modifying existing landscapes, infrastructures and patterns of life?How could we be sure in advance that the changes that new technologies bring will make our society more sustainable? These dilemmas and paradoxes are the subject of this provocative book. Sometimes the claim that a technology is sustainable is made in order to make the technology acceptable in the political process, as in the case of nuclear energy production, where the claims of "sustainability" refer to the absence of CO2 emissions. In the case of biofuels, claims of sustainability have led to a "fuel or food" debate, showing that sustainability has counteracting articulations. And the well-known rebound effect is observed when increased resource efficiency can create a stimulus for consumption. What is Sustainable Technology? illustrates that the sustainability impact of a technology is often much more complicated and ambivalent than one might expect. Making improvements to existing designs is not the technological challenge that will lead to real solutions. We mustn't look to change a part of a machine, but rather the machine as a whole - or even the whole system in which it functions. It is these system innovations that have the potential to make a genuine contribution to sustainable development. What is Sustainable Technology? will help all those involved in designing more sustainable technologies in determining their strategies. It does so by presenting case studies of different technologies in contrasting contexts. Each case asks: 1. What articulations of sustainability played a role in the design process? 2. What sustainability effects did this technology lead to? 3. Who was affected, where, and when? 4. Could the designer have foreseen these consequences? 5. How did the designer anticipate them? 6. How was societal interaction dealt with during the design process? Finally, the authors reflect on future options for the sustainable technology designer. They argue that an important first step is an awareness of the multitude of sustainable development challenges that play a role in production, use, recycling and end-of-life disposal. What is Sustainable Technology? will be essential reading for product designers, engineers, material scientists and others involved in the development of sustainable technologies, as well as a wide academic audience interested in the complexities of the sustainable design process.

This book constitutes thoroughly revised, selected papers of the proceedings of the 6th International Workshop on Collaborative Agents Research and Development, CARE 2015 and the Second International Workshop on Multi-agent Foundations of Social Computing, MFSC 2015, held in Istanbul, Turkey, on May 4, 2015. Both Workshops were held in conjunction with AAMAS 2015. The 5 revised full papers of CARE and the 7 full papers of MFSC presented were carefully selected from 14 CARE and 10 MFSC submissions. Both workshop address issues in relevant areas of social computing such as smart societies, social applications, urban intelligence, intelligent mobile services, models of teamwork and collaboration.

This book analyzes the economic impact of the early development of railways in different Asian countries, linking the inlands with port cities and with a global network of connections. This is looked at in the context of the rise of imperialism in the last decades of the 19th century and the redistribution of spheres of influence in Asia. The book considers the increase of exports of plantation economies in the context of the global market and the importance of China, and the struggle between the great powers for the economic penetration in the Chinese empire. Its comparative approach provides an original contribution to global economic history and will be valuable reading for students and researchers of economic history, transport economics, and Asian history more broadly.

How foreign lending weakens emerging nations In the nineteenth century, many developing countries turned to the credit houses of Europe for sovereign loans to balance their books and weather major fiscal shocks such as war. This reliance on external public finance offered emerging nations endless opportunities to overcome barriers to growth, but it also enabled rulers to bypass critical stages in institution building and political development. Pawned States reveals how easy access to foreign lending at early stages of state building has led to chronic fiscal instability and weakened state capacity in the developing world. Drawing on a wealth of original data to document the rise of cheap overseas credit between 1816 and 1913, Didac Queralt shows how countries in the global periphery obtained these loans by agreeing to "extreme conditionality," which empowered international investors to take control of local revenue sources in cases of default, and how foreclosure eroded a country's tax base and caused lasting fiscal disequilibrium. Queralt goes on to combine quantitative analysis of tax performance between 1816 and 2005 with qualitative historical analysis in Latin America, Asia, Africa, and the Middle East, illustrating how overreliance on external capital by local leaders distorts their incentives to expand tax capacity, articulate power-sharing institutions, and strengthen bureaucratic apparatus. Panoramic in scope, Pawned States sheds needed light on how early and easy access to external finance pushes developing nations into trajectories characterized by fragile fiscal institutions and autocratic politics.

How foreign lending weakens emerging nations In the nineteenth century, many developing countries turned to the credit houses of Europe for sovereign loans to balance their books and weather major fiscal shocks such as war. This reliance on external public finance offered emerging nations endless opportunities to overcome barriers to growth, but it also enabled rulers to bypass critical stages in institution building and political development. Pawned States reveals how easy access to foreign lending at early stages of state building has led to chronic fiscal instability and weakened state capacity in the developing world. Drawing on a wealth of original data to document the rise of cheap overseas credit between 1816 and 1913, Didac Queralt shows how countries in the global periphery obtained these loans by agreeing to "extreme conditionality," which empowered international investors to take control of local revenue sources in cases of default, and how foreclosure eroded a country's tax base and caused lasting fiscal disequilibrium. Queralt goes on to combine quantitative analysis of tax performance between 1816 and 2005 with qualitative historical analysis in Latin America, Asia, Africa, and the Middle East, illustrating how overreliance on external capital by local leaders distorts their incentives to expand tax capacity, articulate power-sharing institutions, and strengthen bureaucratic apparatus. Panoramic in scope, Pawned States sheds needed light on how early and easy access to external finance pushes developing nations into trajectories characterized by fragile fiscal institutions and autocratic politics.

This is a reproduction of a book published before 1923. This book may have occasional imperfections such as missing or blurred pages, poor pictures, errant marks, etc. that were either part of the original artifact, or were introduced by the scanning process. We believe this work is culturally important, and despite the imperfections, have elected to bring it back into print as part of our continuing commitment to the preservation of printed works worldwide. We appreciate your understanding of the imperfections in the preservation process, and hope you enjoy this valuable book. ++++ The below data was compiled from various identification fields in the bibliographic record of this title. This data is provided as an additional tool in helping to ensure edition identification: ++++ Historia De Los Condes De Urgel, 1 Didac Montfar-Sorts Establecimiento Litografico y Tipografico de D. Jose Eusebio Monfort, 1853 Corona catalanoaragonesa

This is a reproduction of a book published before 1923. This book may have occasional imperfections such as missing or blurred pages, poor pictures, errant marks, etc. that were either part of the original artifact, or were introduced by the scanning process. We believe this work is culturally important, and despite the imperfections, have elected to bring it back into print as part of our continuing commitment to the preservation of printed works worldwide. We appreciate your understanding of the imperfections in the preservation process, and hope you enjoy this valuable book. ++++ The below data was compiled from various identification fields in the bibliographic record of this title. This data is provided as an additional tool in helping to ensure edition identification: ++++ Le Chemin Royal De La Croix. Compose Par Dom Benoist Haeften D'Ustrech, ... Traduit De Latin En Francois, & Dedie a Madame La Duchesse D'Orleans. Par Le R. P. Didac, ... Enrichi De Quarante Figures En Taille-douce. Derniere Edition, Revue, Corrigee & Augmen Benedictus Van Haeften, Didac chez Antoine Besson, 1734

Artistic creativity is fuelled by the permanent interaction among artistic forms, cultures, societies, and eventually different individuals, in the form of an all-inclusive intertextuality. The dialogues between the past and the present help the artist examine his own art, making him conscious of his position in the field, whether through self-evaluation, renewal or experiment with new textualities. This book explores how the strategies reflecting the exchanges between past and present modes of artistic production become active agents of intervention in creating the various spaces of dialogue and confrontation when establishing the identities and cultural specificity of a certain society or community.