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Myofibrillogenesis has been studied extensively over the last 100
years. Until recently, we have not had a comprehensive
understanding of this fundamental process. The emergence of new
technologies in molecular and cellular biology, combined with
classical embryology, have started to unravel some of the
complexities of myofibril assembly in striated muscles. In striated
muscles, the contractile proteins are arranged in a highly ordered
three dimensional lattice known as the sarcomere. The assembly of a
myofibril involves the precise ordering of several proteins into a
linear array of sarcomeres. Multiple isoforms in many of these
proteins further complicate the process, making it difficult to
define the precise role of each component. This volume has been
compiled as a comprehensive reference on myofibrillogenesis. In
addition, the book includes reviews on myofibrillar disarray under
various pathological conditions, such as familial hypertrophic
cardiomyopathy (FHC), and incorporates a section on the conduction
system in the heart. Much of the information in this volume has not
been described elsewhere. Presented in a manner to be of value to
students and teachers alike, "Myofibrillogenesis" will be an
invaluable reference source for all in the fields of muscle biology
and heart development.
Myofibrillogenesis has been studied extensively over the last 100
years. Until recently, we have not had a comprehensive
understanding of this fundamental process. The emergence of new
technologies in molecular and cellular biology, combined with
classical embryology, have started to unravel some of the
complexities of myofibril assembly in striated muscles. In striated
muscles, the contractile proteins are arranged in a highly ordered
three dimensional lattice known as the sarcomere. The assembly of a
myofibril involves the precise ordering of several proteins into a
linear array of sarcomeres. Multiple isoforms in many of these
proteins further complicate the process, making it difficult to
define the precise role of each component. This volume has been
compiled as a comprehensive reference on myofibrillogenesis. In
addition, the book includes reviews on myofibrillar disarray under
various pathological conditions, such as familial hypertrophic
cardiomyopathy (FHC), and incorporates a section on the conduction
system in the heart. Much of the information in this volume has not
been described elsewhere. Presented in a manner to be of value to
students and teachers alike, "Myofibrillogenesis" will be an
invaluable reference source for all in the fields of muscle biology
and heart development.
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