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ABC Day (Hardcover)
Dipti Joshi; Illustrated by Sarah Naberhaus
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R571
R480
Discovery Miles 4 800
Save R91 (16%)
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ABC Day (Paperback)
Dipti Joshi; Illustrated by Sarah Naberhaus
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R240
R211
Discovery Miles 2 110
Save R29 (12%)
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Ships in 10 - 15 working days
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Hepatocellular Carcinoma represents about 4% of all malignancies
worldwide. A number of chemopreventive phytochemicals have been
identified which react with prooxidants and prevent damages to DNA
thereby preventing the onset of various diseases. Thioacetamide, a
model hepatotoxicant, undergoes metabolic activation to form
thioacetamide sulfoxide and further metabolized to form
thioacetamide-S, S, - oxide thus initiating hepatocellular necrosis
and further hepatocarcinogenesis. Thioacetamide thus produces
oxidative stress on liver and causes hepatocellular carcinoma. This
oxidative stress can be reversed by the use of antioxidants. Thus,
the aim of this work was to evaluate the anticancer activity of
hydroalcoholic extract prepared from Oroxylum indicum, correlating
the biochemical and histological changes in thioacetamide induced
hepatocellular carcinoma in female Sprague Dawley rats. This
research work should help shed some light on cancer research and
experimental model development for hepatocellular carcinoma, and
should be especially useful to research scholars, scientists and
students working on hepatocellular carcinoma in experimental
animals.
Increase in scientific investigations into indigenious wealth of
herbal medicines gives ample evidence of medicinal plants as
sources of drugs. Hepatocellular Carcinoma represents about 4% of
all malignancies worldwide.Plants contain chemopreventive agents
like phenolic compounds, nitrogen compounds and some other
endogenous metabolites, which are rich in antioxidant activity.
Thioacetamide, a model hepatotoxicant, initiates hepatocellular
necrosis and further hepatocarcinogenesis. Thioacetamide thus
produces oxidative stress on liver and causes hepatocellular
carcinoma. This oxidative stress can be reversed by the use of
antioxidants. Thus, the aim of this work was to evaluate the
anticancer activity of hydroalcoholic extract prepared from
Casearia esculenta, correlating the biochemical and histological
changes in thioacetamide induced hepatocellular carcinoma in female
Sprague Dawley rats. This research work should help shed some light
on cancer research and experimental model development for
hepatocellular carcinoma, and should be especially useful to
research scholars, scientists and students working on
hepatocellular carcinoma in experimental animals.
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