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This is comprehensive overview of a vital area of scientific
enquiry, which covers a broad spectrum of issues. With
contributions from some of the key researchers in the field, Adult
Stem Cells: Biology and Methods of Analysis offers readers a
historical perspective as well as unique insights into cutting-edge
thoughts. The volume contextualizes the recent discovery of
stem/progenitor cell populations resident in many adult tissues and
organs. It confronts the complexities scientists face in trying to
validate these cells, while it also describes and critically
evaluates the methods currently used to assess stem cell
self-renewal. The chapters also seek to distinguish this process
from other aspects of cell survival, such as the regulation of life
span, senescence, and immortalization at a molecular level. The
monograph begins with a section that examine the basic biology of
adult stem cells, including chapters on the emerging role of
microRNAs in regulating their fate and the molecular mechanisms
that govern their self-renewal, the book moves on to analyze the
varying methodologies employed in characterizing these elusive
elements of our genetic make-up. The second section details in-vivo
lineage tracing of tissue-specific stem cells, explores the neural
stem cell paradigm, and considers the function of ABC transporters
and aldehyde dehydrogenase in adult stem-cell biology. The final
section shifts the focus to the life-span regulation and
immortalization and features a chapter on the cancer stem cell
paradigm. This is an authoritative volume on one of the frontiers
of genetic research, and will serve as a valuable resource, not
just for established scientists but also for those now entering the
field of stem cell biology.
For over forty years, mesenchymal stem cells (MSCs) have been
scrutinized and studied, garnering much attention due to their
broad therapeutic efficacy. In this essential book, leaders in the
field were assembled to contribute detailed methodologies for the
isolation and characterization of human and rodent MSCs. Cutting
edge and easy to use, this book is the perfect resource for
scientists attempting to pursue this important and ever-developing
field of research.
For over forty years, mesenchymal stem cells (MSCs) have been
scrutinized and studied, garnering much attention due to their
broad therapeutic efficacy. In Mesenchymal Stem Cells: Methods and
Protocols, leaders in the field were assembled to contribute
detailed methodologies for the isolation and characterization of
human and rodent MSCs. Recently, these vital cells have shown
therapeutic benefits in the treatment of myocardial infarction,
stroke, lung diseases, spinal cord injury and other neurological
disorders, thus promising a boundless future in their study.
Cutting edge and easy to use, Mesenchymal Stem Cells: Methods and
Protocols is the perfect resource for scientists attempting to
pursue this important and ever-developing field of research.
This is comprehensive overview of a vital area of scientific
enquiry, which covers a broad spectrum of issues. With
contributions from some of the key researchers in the field, Adult
Stem Cells: Biology and Methods of Analysis offers readers a
historical perspective as well as unique insights into cutting-edge
thoughts. The volume contextualizes the recent discovery of
stem/progenitor cell populations resident in many adult tissues and
organs. It confronts the complexities scientists face in trying to
validate these cells, while it also describes and critically
evaluates the methods currently used to assess stem cell
self-renewal. The chapters also seek to distinguish this process
from other aspects of cell survival, such as the regulation of life
span, senescence, and immortalization at a molecular level. The
monograph begins with a section that examine the basic biology of
adult stem cells, including chapters on the emerging role of
microRNAs in regulating their fate and the molecular mechanisms
that govern their self-renewal, the book moves on to analyze the
varying methodologies employed in characterizing these elusive
elements of our genetic make-up. The second section details in-vivo
lineage tracing of tissue-specific stem cells, explores the neural
stem cell paradigm, and considers the function of ABC transporters
and aldehyde dehydrogenase in adult stem-cell biology. The final
section shifts the focus to the life-span regulation and
immortalization and features a chapter on the cancer stem cell
paradigm. This is an authoritative volume on one of the frontiers
of genetic research, and will serve as a valuable resource, not
just for established scientists but also for those now entering the
field of stem cell biology.
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