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Drug metabolism and transport are very important facets within the
discipline of pharmaceutical sciences, with enzyme kinetic concepts
utilized regularly in characterizing and modeling the disposition
and elimination of drugs. Enzyme Kinetics in Drug Metabolism:
Fundamentals and Applications focuses on very practical aspects of
applying kinetic principles to drug metabolizing enzymes and
transporters. Divided into five convenient sections, topics include
the fundamental principles of enzyme kinetics, the kinetics of
oxidative and conjugative drug metabolizing enzymes and drug
transporters, modeling approaches for both drug metabolizing
enzymes and transporters including novel systems biology
approaches, understanding of variability both experimental and
interindividual (pharmacogenomic), and case studies that provide
real life examples of applying these principles. Written in the
successful Methods in Molecular Biology series format, chapters
include introductions to their respective topics especially
suitable for the novice, in some cases step-by-step, readily
reproducible protocols, and insights to help with troubleshooting
and avoiding known pitfalls with extensive cross referencing to
assist in learning. Authoritative and easily accessible, Enzyme
Kinetics in Drug Metabolism: Fundamentals and Applications serves
as a very practical teaching tool for novice, non-mathematically
trained scientists interested in these fundamental concepts and as
an aid for their supervisors in teaching these principles.
Drug metabolism and transport are very important facets within the
discipline of pharmaceutical sciences, with enzyme kinetic concepts
utilized regularly in characterizing and modeling the disposition
and elimination of drugs. Enzyme Kinetics in Drug Metabolism:
Fundamentals and Applications focuses on very practical aspects of
applying kinetic principles to drug metabolizing enzymes and
transporters. Divided into five convenient sections, topics include
the fundamental principles of enzyme kinetics, the kinetics of
oxidative and conjugative drug metabolizing enzymes and drug
transporters, modeling approaches for both drug metabolizing
enzymes and transporters including novel systems biology
approaches, understanding of variability both experimental and
interindividual (pharmacogenomic), and case studies that provide
real life examples of applying these principles. Written in the
successful Methods in Molecular Biology series format, chapters
include introductions to their respective topics especially
suitable for the novice, in some cases step-by-step, readily
reproducible protocols, and insights to help with troubleshooting
and avoiding known pitfalls with extensive cross referencing to
assist in learning. Authoritative and easily accessible, Enzyme
Kinetics in Drug Metabolism: Fundamentals and Applications serves
as a very practical teaching tool for novice, non-mathematically
trained scientists interested in these fundamental concepts and as
an aid for their supervisors in teaching these principles.
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