This second edition further develops the principles of applying kinetic principles to drug metabolizing enzymes and transporters. Chapters are divided into six sections detailing fundamental principles of enzyme kinetics, enzyme and transporter structures, highlighting specific oxidative and conjugative drug metabolizing enzymes and drug transporters, modeling approaches for drug metabolizing enzymes and transporters, understanding of variability both experimental and interindividual (pharmacogenomic), and expanded case studies that provide real life examples of applying these principles. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, in some cases step-by-step instructions with readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls with extensive cross referencing to assist in learning. Authoritative and fully updated, Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications, Second Edition serves as a practical teaching tool for novice and advanced scientists interested in the fundamental concepts.

"Office Space Planning and Management" gives managers explicit and practical guidelines and standards for use in planning and managing office space, assessing present and future needs, introducing new systems, and ordering new furniture and equipment. Donald B. Tweedy presents common-sense thinking, numerous illustrations, checklists, diagrams, and alternative routes to more effective space utilization. He shows the reader how to analyze existing space and layouts and plan for office automation and new workcenters. He cogently addresses the goals of space management and offers detailed suggestions for achieving maximum efficiency and economy from available space and workers; having sufficient space for all operations while assuring the comfort and convenience of all workers; balancing capabilities of equipment and personnel; designing workcenters and stations that permit supervision and show sensitivity to the needs of interpersonal communication; and allowing flexibility for future changes. He emphasizes the necessity of coordinating such environmental factors as ventilation, heat, safety, light, noise, security, and decor and provides industry standards for lighting, acoustics, furniture, and equipment.

This second edition further develops the principles of applying kinetic principles to drug metabolizing enzymes and transporters. Chapters are divided into six sections detailing fundamental principles of enzyme kinetics, enzyme and transporter structures, highlighting specific oxidative and conjugative drug metabolizing enzymes and drug transporters, modeling approaches for drug metabolizing enzymes and transporters, understanding of variability both experimental and interindividual (pharmacogenomic), and expanded case studies that provide real life examples of applying these principles. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, in some cases step-by-step instructions with readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls with extensive cross referencing to assist in learning. Authoritative and fully updated, Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications, Second Edition serves as a practical teaching tool for novice and advanced scientists interested in the fundamental concepts.