This book summarizes the recent advances for the understanding of circadian clock system in the regulation of drug metabolism and pharmacokinetics. Basic knowledge in the field of circadian clock and pharmacokinetics are systemically introduced to make it easier for readers to understand the entire book's contents. The rhythmic expression of DMEs (drug-metabolizing enzymes) and transporters are summarized, and the underlying mechanisms thereof (i.e., regulation by circadian oscillators) are discussed. Typically, evidence for the DME- and transporter-mediated chronopharmacokinetics, chronotoxicity and chronoefficacy are highlighted in this book.

This book tackles the infodemic—the rapid, widespread diffusion of false, misleading, or inaccurate information about the disease and its ramifications—triggered by the COVID-19 pandemic. With a focus on four Asian societies, the book compares and analyzes the spread of COVID-19 misinformation and its broad impacts on the public in Beijing, Hong Kong, Taipei, and Singapore. Providing both a comprehensive overview of the phenomenon of misinformation and cross-societal analyses of patterns, the book features in-depth analyses of the prevalence of COVID-19 misinformation and engagement and explores its consequences in an Asian context. The book sheds lights on these key questions: What types of infodemic messages circulate widely on popular social media platforms? What factors account for exposure to and engagement with debunked yet popular COVID-19 misinformation? How does exposure to widely circulated COVID-19 misinformation affect people’s beliefs, attitudes, and adoption of preventive measures to cope with the pandemic? How do macro social differences condition the diffusion and impacts of COVID-19 misinformation? What intervention strategies can counter the misinformation? Presenting scientific insights and empirical findings on the pressing issues about infodemic, this book will be of great interest to students and researchers of communication studies, political science, public health, crisis communication, and Asian Studies, as well as policymakers and practitioners who wish to acquire cutting-edge, evidence-based knowledge about combating misinformation during a global pandemic.

This book summarizes the recent advances for the understanding of circadian clock system in the regulation of drug metabolism and pharmacokinetics. Basic knowledge in the field of circadian clock and pharmacokinetics are systemically introduced to make it easier for readers to understand the entire book's contents. The rhythmic expression of DMEs (drug-metabolizing enzymes) and transporters are summarized, and the underlying mechanisms thereof (i.e., regulation by circadian oscillators) are discussed. Typically, evidence for the DME- and transporter-mediated chronopharmacokinetics, chronotoxicity and chronoefficacy are highlighted in this book.

Where is the market? inquires the tourist one dark, chilly morning. Follow the ghosts, responds the taxi driver, indicating a shadowy parade of overloaded tricycles. It s not called the ghost market for nothing And indeed, Beijing is nothing if not haunted. Among the soaring skyscrapers, choking exhaust fumes, nonstop traffic jams, and towering monuments, one discovers old Beijing newly styled, perhaps, but no less present and powerful than in its ancient incarnation. "Beijing Time" conducts us into this mysterious world, at once familiar and yet alien to the outsider.

The ancient Chinese understood the world as enchanted, its shapes revealing the mythological order of the universe. In the structure and detail of Tian anmen Square, the authors reveal the city as a whole. In Beijing no pyramids stand as proud remnants of the past; instead, the entire city symbolizes a vibrant civilization. From Tian anmen Square, we proceed to the neighborhoods for a glimpse of local color from the granny and the young police officer to the rag picker and the flower vendor. Wandering from the avant-garde art market to the clock towers, from the Monumental Axis to Mao s Mausoleum, the book allows us to peer into the lives of Beijingers, the rules and rituals that govern their reality, and the mythologies that furnish their dreams. Deeply immersed in the culture, everyday and otherworldly, this anthropological tour, from ancient cosmology to Communist kitsch, allows us to see as never before how the people of Beijing and China work and live.

The main purpose of this book is to explore the influences of reform on changes in China's economic relations with Japan after the late 1970s. There are three reasons for investigating the links between Chinese reform and bilateral economic relations at this particular juncture in history. First, in the past two decades reform has meant that China has enjoyed faster economic growth then Japan. This has transformed the pattern of bilateral economic relations, hitherto characterised by an industrial Japanese economy and a resource-based Chinese economy, a result of Japan's successful industrialisation and China's failure to industrialise in the previous hundred years. Second, reform has brought about the deepening of the interdependence between the Chinese economy and the world economy. Through links with the world economy, the Chinese economy has not only come to rely on foreign countries for technology, capital, markets and management skills, but has itself become a growth pole, exerting a strong impact on world economic growth. In the reform era, economic relations between China and Japan have been woven into regional and global economic networks of trade an investment. Third, reform has transformed the management of China's domestic and external economic activities.