The investigation of HAART adherence behavior and its effect on those under therapy in Uganda is important, especially because provision of HAART in low-income nations-such as those in sub-Saharan Africa, where many of the affected individuals are poverty stricken and possess little or no formal education-may result in negative public health implications, including those resulting from suboptimal adherence, such as drug resistance. In exploring the effect of HAART on sexual behavior of those under therapy, this study may augment existing knowledge pertaining to this area in resource-constrained nations. Of supreme importance, this study may assist in the formulation of strategies and policies that could enhance the effect of HAART and the quality of life for those with HIV/AIDS in developing nations such as Uganda.