In a world beset by serious and unconscionable health disparities, by dangerous contagions that can circle our globalized planet in hours, and by a bewildering confusion of health actors and systems, humankind needs a new vision, a new architecture, new coordination among renewed systems to ensure central health capabilities for all. Global Health Justice and Governance lays out the critical problems facing the world today and offers a new theory of justice and governance as a way to resolve these seemingly intractable issues. A fundamental responsibility of society is to ensure human flourishing. The central role that health plays in flourishing places a unique claim on our public institutions and resources, to ensure central health capabilities to reduce premature death and avoid preventable morbidities. Faced with staggering inequalities, imperiling epidemics, and inadequate systems, the world desperately needs a new global health architecture. Global Health Justice and Governance lays out this vision.