Jeckle appears more human than dog. However, his attorney and barking interpreter, Juan Antonio, consistently argues that he should be judged as a dog. First, Jeckle is arraigned as an adult on several serious felony charges, before being transferred to juvenile court. There, he testifies about his experience in the K9 unit, goes after a flipped bone, and both he and Juan Antonio end up in juvenile hall. After Jeckle's escape, the two protagonists are returned to adult court for a preliminary hearing that leads to Flatton mental hospital and a ninety-day dognostic study to determine their competency to go to trial.

Once at Flatton, Jeckle and Juan Antonio find themselves at the mercy of a giant counselor and a psycho/psychiatrist. At the end of the dognostic study, a riot allows all dogs to escape. The fleeing dogs soon find themselves racing south on California freeways and being pursued by helicopters, police, the news media, Governor Schwarzendogger, and others. The run leads into Mexico where the dogs run a race at a Tijuana dog racetrack and later party at Rosarito Beach. Unfortunately, Jeckle is finally extradited to Los Angeles to stand trial for all his alleged atrocities.