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This volume summarizes the proceedings of the fifth biennial Cancer
Teaching Symposium held on March 4 and 5, 1972 at the University of
Chicago Pritzker School of Medicine. The program was prepared by
Drs. MELVIN GRIEM, ELWOOD JENSEN, HAROLD SUTTON, JOHN ULTMANN, and
ROBERT WISSLER. The purpose of the symposium was to present the
current status of the challenging cancer problem, breast carcinoma,
to the staff and students of this medical center and to students
and in terested physicians from other institutions in the Chicago
area. In a fashion similar to the other teaching symposia held in
1964, 1966, 1968, . and 1970, this symposium attracted over 450
physicians and scientists. In the course of one and one half days
the audience had the opportunity to listen to 18 invited speakers
and to the lively discussions. The formal presentations are
recorded in these pages. This teaching symposium could not have
been undertaken without the faithful assistance of the program
committee, the cancer training grant education committee, the staff
who recorded and transcribed the proceedings, and the editorial
assistants. We wish to thank the following for their efforts: JULIE
KANT, Administrative Secre tary for the Clinical Cancer Training
Grant, as well as Dr. JAMES MARKS, MARGARET WOEHRLE, FRIEDA RANNEY,
and ROSIE BARTLETT. This symposium received financial support from
USPHS Clinical Cancer Train ing Grant 5T12 CA-08077-06 and from the
Chicago Tumor Institute. MELVIN L. GRIEM, M. D. ROBERT W. WISSLER,
Ph. D., M. D."
The methods of molecular biology, biochemistry, immunocytochem
istry, and in-situ hybridization introduce new opportunities for
the classification and functional characterization of cell
receptors under normal conditions and for a better understanding of
pathogenetic mechanisms in human diseases. The cellular
localization and trans location of receptor proteins can be
identified using morphological methods, and it is apparent that
receptors and receptor defects play an important role in pathology,
notably in genetic diseases, endocrine disorders, atherosclerosis,
infections, and cancer. In this volume in ternational experts give
a current review of the morphology and pathological aspects of cell
receptors. The complex communication of multicellular organisms is
coordi nated by two regulatory systems: neural and humoral. Both
systems function via signaling substances (ligands) and
signal-recognizing and -transmitting molecules, called receptors.
The historical develop ment of the receptor concept is based upon
Paul Ehrlich's theory of "receptors in the immune system,"
Langley's "receptive substances in postssynaptic membranes," and
Earl Sutherland's discovery of "sec ond messengers" (cAMP and
Ca2])."
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