Contents

Philip C. Sharpe, Rosemary S. Harrison, and David P. Fairlie: Amyloid Peptides and Proteins in Review. - Marilena Kampa, Artemissia-Phoebe Nifli, George Notas, Elias Castanas: Polyphenols and Cancer Cell Growth. - Michal Janitz: Assigning Functions to Genes The Main Challenge of the Post-Genomic Era. - Brigittte M. Jockusch, Kai Murk and Martin Rothkegel: The Profile of Profilins.

Contents

E.I. Christensen and R. Nielsen: Role of Megalin and Cubilin in Renal Physiology and Pathophysiology

G. Zifarelli and M. Pusch: CLC Chloride Channels and Transporters: A Biophysical and Physiological Perspective

S.F.J. van de Graaf, R.J.M. Bindels and J.G.J. Hoenderop: Physiology of Epithelial Ca2 and Mg2+ Transport

D. Kamimura, K. Ishihara, T. Hirano: IL-6 Signal Transduction and its Physiological Roles: The Signal Orchestration Model

M. Tanaka and A. Miyajima: Oncostatin M, a Multifunctional Cytokine

G.-J. van de Geijn, L.H.J. Aarts, S.J. Erkeland, J. Prasher, and I.P. Touw: Granulocyte Colony-Stimulating Factor and its Receptor in Normal Hematopoietic Cell Development and Myeloid Disease

T. Hanada, I. Kinjyo, K. Inagaki-Ohara and A. Yoshimura: Negative Regulation of Cytokine Signaling by CES/SOCS Family Proteins and Their Roles in Inflammatory Diseases

J. Kalesnikoff, L.M. Sly, M.R. Hughes, T. B chse, M.J. Rauh, L.-P. Cao, V. Lam, A. Mui, M. Huber, and G. Krystal: The Role of SHIP in Cytokine-Induced Signaling

Embryonic and Adult Stem-Cell Derived Cardiomyocytes: Lessons from in vitro Models.- Phylogenesis of Constitutively Formed Nitric Oxide in Non-Mammals.- Dimensions of Systems Biology.- Structures, Mechanism, Regulation and Evolution of Class III Nucleotidyl Cyclases

In the series Reviews of Physiology, Biochemistry and Pharmacology three excellent contributions by Ruth Heidelberger (Houston, TX, USA) with Electrophysiological Approaches to the Study of Neuronal Exocytosis and Synaptic Vesicle Dynamics and Kay Truscott et al. (Freiburg, Germany) with Transport of Proteins Into Mitochondria and Randall K. Powers and Marc D. Binder (Seattle, WA, USA) with Input-Output Functions of Mammalian Motoneurons form another outstanding volume.