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Most often when the subject of antimicrobial resistance is
discussed, the organizational emphasis is on individual
antimicrobial agents or groups of agents. Thus we tend to see
discussion of resistance to f3-lactams, tetracyclines, amino
glycosides etc. In this book many of the authors were asked to
emphasize the mechanism of resistance in their discussion and from
that to show how susceptibility to various agents was affected. In
part this was done to help emphasize the enormous contribution that
the study of antimicrobial resistance has made to our understanding
of fundamental physiologic and genetic processes in bacteria. When
one looks back over the study of antimicrobial resistance, it is
clear that it has been the birthplace of many fundamental advances
in molecular biology and of an appreciation of the role of many key
functions in the life of a bacterium. In addition, and hopefully to
an increasing extent in the future, such study has also contributed
to advances in antimicrobial chemotherapy. Through out the book
resistance mechanisms have been placed in perspective as to their
significance as causes of resistance to key drugs or groups of
drugs. Some are of much greater significance than others in terms
of the prevalence or the degree of resistance produced. Whatever
their numerical significance, however, each of the mechanisms,
without question, throws light on fundamental cellular processes
and the way in which they interact with antimicrobial agents."
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