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Nuclear receptors are the site of action for some of the most
widely used medications, namely oral contraceptives and related
drugs derived from steroid hormones. Recent research has uncovered
their pivotal role in a range of human diseases, including diabetes
and metabolic syndrome, triggering a new wave of drug discovery
efforts focused on this class of molecular targets.
Edited by two experts working at the pioneering pharmaceutical
company and major global player in hormone-derived drugs, this
handbook systematically treats the drug development aspects of all
human nuclear receptors, including such recently characterized
receptors as PPAR, FXR and LXR, and modern tools for nuclear
receptor research.
With its contributions from authors working at leading
pharmaceutical companies around the world providing examples and
real-life data from their own experience, this is an invaluable
reference for medicinal chemists, biochemists, molecular
biologists, pharmacologists and those working in the pharmaceutical
industry.
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