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Much of the attention presently paid to leukemia is the result of
recent progress in understanding and treatment. Chemotherapy of
leukemia started in the late 1940s, and combination therapy evolved
in the late 1950s. It was at that time that the clonality of
leukemia was realized, after the discovery of chromosomal and then
biochemical and immunological markers. And now we have the new data
on retroviral and cellular oncogenes and the reports on human T
-cell lymphoma/ leukemia viruses. Many more steps forward could be
enumerated in a field which is so rapidly making the hematological
textbooks outdated. In this volume, thirteen in-depth reviews from
large multicenter trials in the Federal Republic of Germany
summarize the current state of diagnosis and management of
leukemias. Childhood ALL and AML adult ALL and AUL were
investigated. While cure appears to be achievable for more and more
patients with acute leukemia, we still pursue the aim of optimal
palliation in chronic leukemias. The management of patients with
leukemia therefore varies to a large extent in aggressiveness of
therapy. In some situations, rescue from an otherwise lethal
disease is provided by bone marrow transplanta tion, which is
discussed in two chapters."
This two-and-a-half-day symposium has concentrated on main aspects
of the rapidly expanding field ofleukocyte markers in hematology.
While leukemias are already being 'phenotyped' routinely in
clinical centers, continued research on the developmental sta ge of
cells and cell membranes, expanding into a malignant clone, permits
new snap shots on hemopoietic differentiation. Thus the discovery
of leukemia-associated anti gens, which so far have not been found
on subpopulations of normal cells, has greatly stimulated the
discussion on 'differentiation antigens versus tumor antigens'. The
proceedings reflect the considerable success which has been
achieved very re cently in the classification of hemoblastomas.
Consequently the number of leukemias which are unclassifiable by
immunological methods have dwindled down to a small mi nority. New
facts give rise to new questions. By including the main points of
the discussions in the proceedings, we wanted to give the reader an
opportunity to get an impression of the questions and conclusions
raised and drawn by the participants on the basis of new - and
frequently still unpublished - data. The editors thank both the
contributors to this symposium, who made it a successful meeting
and submitted their manuscripts punctually, and the publishers, who
have provided a volume of high quality in good time. They are also
grateful for the valuable cooperation from numerous colleages at
the Institut fUr Hamatologie.
The Role of Neuropeptides in Addiction and Disorders of Excessive
Consumption, Volume 136 in the International Review of Neurobiology
series, provides an overview of the top candidate neuropeptides in
the modulation of alcohol and drug abuse, also covering eating
disorders and obesity. Topics covered in this latest release
include Corticotropin Releasing Factor (CRF) and Addictive
Behaviors, Dynorphin/Kappa Opioid Receptor Signaling in
Pre-clinical Models of Alcohol, Drug, and Food Addiction, The Role
of Ghrelin Signaling in Additive Behaviors, The Role of the
Melanocortin System in Drug and Eating Disorders, Substance P and
the Neurokinin-1 Receptor: The New CRH, and the Role of
Neuropeptide Y (NPY) in Drug and Eating Disorders. The book
uniquely highlights the overlapping central mechanisms that
contribute to both drug and alcohol abuse and eating disorders.
Building on the insights of the ressourcement theology of grace,
this sophisticated theological aesthetics offers a fresh vision of
the doctrine of creation through a consideration of the beauty of
time. Conventional eschatological accounts of life after death tend
to emphasize the discontinuity between earthly life and the
hereafter: whereas this life is subject to the contingencies of
time, life after death is characterized by a stolid eternity. In
contrast to this standard view, John E. Thiel's Now and Forever
articulates a Catholic eschatology in which earthly life and
heavenly life are seen as gracefully continuous. This account
offers a reconceptualization of time, which, Thiel argues, is best
understood as the sacramental medium of God's grace to creation.
Thiel's project thus attempts to rescue time from its Platonically
negative resonance in the doctrine of creation. Rather than viewing
time as the ambiance of sinful dissolution, Thiel argues for a
Christian vision of time's beauty, and so explicitly develops an
aesthetics that views time as a creaturely reflection of God's own
Trinitarian life. This thesis proceeds from the assumption that all
time is eschatological time and is thus guided by attention to the
temporality implicit in the virtue of hope, with its orientation
toward a fulfilled future that culminates in resurrected life. This
interpretation of the beauty of eschatological time in its widest
expanse presses further the insight of ressourcement theology that
grace is everywhere, while appreciating how time's graceful beauty
manifests itself in the diversity of temporal moments, human
communities, and most fully in the heavenly communion of the
saints.
This book articulates a theory of Catholic tradition that departs from previous understandings. Drawing on the medieval concept of the four-fold sense of scripture, John Thiel proposes four interpretive senses of tradition. He also offers a theory of doctrinal development that reconciles Catholic belief in apostolic authority and continuity of tradition with a critical approach to the evidence of history.
In Icons of Hope: The "Last Things" in Catholic Imagination, John
Thiel, one of the most influential Catholic theologians today,
argues that modern theologians have been unduly reticent in their
writing about "last things": death, judgment, heaven, and hell.
Beholden to a historical-critical standard of interpretation, they
often have been reluctant to engage in eschatological reflection
that takes the doctrine of the "last things" seriously as real
events that Christians are obliged to imagine meaningfully and to
describe with some measure of faithful coherence. Modern theology's
religious pluralism leaves room for a speculative style of
interpretation that issues in icons of hope-theological portraits
of resurrected life that can inform and inspire the life of faith.
Icons of Hope presents an interpretation of heavenly life, the Last
Judgment, and the communion of the saints that is shaped by a view
of the activity of the blessed dead consistent with Christian
belief in the resurrection of the body, namely, the view that the
blessed dead in heaven continue to be eschatologically engaged in
the redemptive task of forgiveness. Thiel offers a revision of the
traditional Catholic imaginary regarding judgment and life after
death that highlights the virtuous actions of all the saints in
their heavenly response to the vision of God. These constructive
efforts are fostered by Thiel's conclusions on the disappearance of
the concept of purgatory in large segments of contemporary Catholic
belief, a disappearance attributable to the emergence of a
noncompetitive spirituality in postconciliar Catholicism, which has
eclipsed the kinds of religious sensibilities that made belief in
purgatory a practice in earlier centuries. This noncompetitive
spirituality-one that recovers traditional Pauline sensibilities on
the gratuitousness of grace-encourages an eschatological imaginary
of mutual, ongoing forgiveness in the communion of the saints in
this life and in the life to come.
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