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The 5th Pathogenic Neisseriae Conference was held in
Noordwijkerhout, The Netherlands, on 15-18 September 1986. It
followed San Francisco - USA (1978), Hemavan - Sweden (1980),
Montreal - Canada (1982), Asilomar - USA (1984). These conferences
will continue to be held in the foreseeing future. The reason for
this is because studying pathogenic Neisseriae enables research
workers to look at many aspects of bacterial infectious diseases.
These aspects include: - Epidemiology and vaccination (section 1) -
Genetic aspects of antigenic diversity (section 2) - Outer membrane
proteins and IgA-protease (section 3) - Lipopolysaccharides, H8
antigen and peptidoglycan (section ~) - The application of all this
knowledge to study pathogenesis (section 5) N. gonorrhoeae has
become an important model organism to study mucosal bacterial
infectious diseases. Basic knowledge about the bacterial surface,
gene- tics and physiology is linked to pathogenic mechanisms such
as adhesion to and invasion of epithelial cells, interaction with
complement and phagocytic cells and mucosal immune mechanisms. This
will continue to be an important research field in the near future.
N. meningitidis has become an important model organism to study the
epide- miology of potentially epidemic bacterial diseases and
against which new type of vaccines are being developed such as
outer membrane protein vaccines. The above mentioned topics are
covered by papers presented at The 5th Path- ogenic Neisseriae
Conference, 1986. I would like to thank Marijke van de Nadort
without whom it would have been much harder or even impossible to
organize such a meeting.
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