Drug development today needs to balance agility, speed, and risk in defining probability of success for molecules, mechanisms, and therapeutic concepts. New techniques such as fMRI promise to be part of a sequence that could transform drug development. Although numerous review articles exist that discuss the use of imaging in drug development, no one source is available that combines the various techniques and includes a discussion of disease mapping.

Imaging in CNS Drug Discovery and Development, Implications for Disease and Therapy will serve to distill the most salient developments in the use of imaging in drug development and disease mapping. It will launch evolving concepts that integrate new imaging technologies and paradigms with molecular medicine and molecular profiling ("monics") as well as consider the ethical issues that arise as a result of disease or state diagnosis and the use of imaging in the public eye.

The rapidly growing field of immunopsychiatry combines expertise and insights from immunology, psychiatry and neuroscience to understand the role of inflammation and other immune processes in causing and treating mental illness. This represents a major shift in mental health science, traditionally focused on psychological and neuronal mechanisms of depression, psychosis and dementia. This book provides the first comprehensive overview of recent, inter-disciplinary research linking disordered function of the immune system to the brain and mental illness. It offers a broad and deep perspective on the implications of immune system involvement in psychiatric disorders, including a balanced focus on basic science and clinical applications. Chapters cover the scientific evidence linking immune processes to major mental illnesses such as schizophrenia, depression, anxiety and dementia. An invaluable guide for graduate students, doctors in training, scientific researchers and others interested in the link between the immune system and mental health.

Worldwide, depression will be the single biggest cause of disability in the next 20 years. But treatment for it has not changed much in the last three decades. In the world of psychiatry, time has apparently stood still... until now. In this game-changing book, Professor Edward Bullmore reveals the breakthrough new science on the link between depression and inflammation. He explains how and why mental disorders can have their roots in the immune system and explores a whole new way of looking at how mind, brain and body all work together in a sometimes misguided effort to help us survive in a hostile world.

"Fundamentals of Human Imaging Connectomics" is the first book to provide an accessible, practical, and comprehensive introduction to imaging connectomics for researchers of any background. Written by experts in all areas of the field, this book contains nontechnical, conceptual, and instructive discussion of each of the core principles of imaging connectomics. Featuring intuitive diagrams, graphical illustrations of key concepts, step-by-step explanations of mathematical formulae, and recommendations for best practices, "Fundamentals of Human Imaging Connectomics" is an indispensable guide for researchers studying the human connectome.
The only volume to offer a step-by-step introduction to connectomics suitable for both researchers and students.Provides a general overview, discussion of various issues involved in using neuroimaging to build a connectomic map, the main measures used to analyze connectomic data, an intro to advanced topics in the field, and discussion of as yet unresolved issues and future directions.Helps readers determine how they can best use fMRI/DTI data to make a brain network, how they can analyze that network using graph theory, and how they can compare/interpret their findings across different groupsAssumes no prior knowledge beyond basic training in human MRI, and adopts a consistent format across chapters to facilitate learning and linking of different concepts

Drug development today needs to balance agility, speed, and risk in defining probability of success for molecules, mechanisms, and therapeutic concepts. New techniques such as fMRI promise to be part of a sequence that could transform drug development. Although numerous review articles exist that discuss the use of imaging in drug development, no one source is available that combines the various techniques and includes a discussion of disease mapping. Imaging in CNS Drug Discovery and Development, Implications for Disease and Therapy will serve to distill the most salient developments in the use of imaging in drug development and disease mapping. It will launch evolving concepts that integrate new imaging technologies and paradigms with molecular medicine and molecular profiling ("monics") as well as consider the ethical issues that arise as a result of disease or state diagnosis and the use of imaging in the public eye.