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In this issue of Clinics in Geriatric Medicine, guest editors
Edward Schneider and Brandon K. Koretz bring their considerable
expertise to the topic of polypharmacy. Provides in-depth reviews
on the latest updates in polypharmacy, providing actionable
insights for clinical practice. Presents the latest information on
this timely, focused topic under the leadership of experienced
editors in the field; Authors synthesize and distill the latest
research and practice guidelines to create these timely topic-based
reviews.
The Genetics of Aging is divided into several sections in an
attempt to provide a logical progression from the level of the
genome to the realm of human genetics. The relationship between the
genetic material and aging will be thoroughly explored in the
initial chapters. These chapters discuss in depth the various
theories that have been proposed for the mechanisms of aging at the
molecular level and present data which either support or contradict
these hypotheses. Subsequent chapters will deal with the genetics
of aging in organisms ranging from paramecium to mammals. The
largest section of this volume will be devoted to several important
areas in human genetics: human genetic disorders which feature
premature aging, the effect of human parental aging on the
production of genetically abnor mal offspring, the genetics of
human longevity, and a review of studies on aging human twins. Over
the last few decades genetic technology has provided enormous
insight into a number of disciplines. Therefore, in the last few
chapters, several genetic approaches to the study of aging are
discussed: somatic cell genetics, immunogenetics, and behavioral
genetics. As the goal of this volume is to present a comprehensive
examination of the genetics of aging, most chapters are oriented
toward general review of their respective areas. It is my hope that
this volume will encourage clinical, biological, and behavioral
investigators to turn their attention to the genetic aspects of
aging as well as to employ genetic technology to obtain further
insight into aging processes."
Abramo Basevi published his study of Verdi's operas in Florence in
1859, in the middle of the composer's career. The first thorough,
systematic examination of Verdi's operas, it covered the twenty
works produced between 1842 and 1857 - from Nabucco and Macbeth to
Il trovatore, La traviata, and Aroldo. But while Basevi's work is
still widely cited and discussed - and nowhere more so than in the
English-speaking world - no translation of the entire volume has
previously been available. The Operas of Giuseppe Verdi fills this
gap, at the same time providing an invaluable critical apparatus
and commentary on Basevi's book. As a contemporary of Verdi and a
trained musician, erudite scholar, and critic conversant with
current and past operatic repertories, Basevi presented pointed
discussion of the operas and their historical context, offering
today's readers a unique window into many aspects of operatic
culture, and culture in general, in Verdi's Italy. He wrote with
precision on formal aspects, use of melody and orchestration, and
other compositional features, which made his study an acknowledged
model for the growing field of music criticism. Carefully annotated
and with an engaging introduction and detailed glossary by editor
Stefano Castelvecchi, this translation illuminates Basevi's musical
and historical references as well as aspects of his language that
remain difficult to grasp even for Italian readers. Making Basevi's
important contribution to our understanding of Verdi and his operas
available to a broad audience for the first time, The Operas of
Giuseppe Verdi will delight scholars and opera enthusiasts alike.
Fear of mad cow disease, a lethal illness transmitted from infected
beef to humans, has spread from Europe to the United States and
around the world. Originally published to much acclaim in France,
this scientific thriller, available in English for the first time
and updated with a new chapter on developments in 2001, tells of
the hunt for the cause of an enigmatic class of fatal brain
infections, of which mad cow disease is the latest incarnation. In
gripping, nontechnical prose, Maxime Schwartz details the deadly
manifestations of these diseases throughout history, describes the
major players and events that led to discoveries about their true
nature, and outlines our current state of knowledge. The book
concludes by addressing the question we all want answered: should
we be afraid? The story begins in the eighteenth century with the
identification of a mysterious illness called scrapie that was
killing British sheep. It was not until the 1960s that scientists
understood that several animal and human diseases, including
scrapie, were identical, and together identified them as
transmissible spongiform encephalopathy (TSE). The various guises
assumed throughout history by TSE include an illness called kuru in
a cannibalistic tribe in Papua New Guinea, an infectious disease
that killed a group of children who had been treated for growth
hormone deficiencies, and mad cow disease. Revealing the
fascinating process of scientific discovery that led to our
knowledge of TSE, Schwartz relates pivotal events in the history of
biology, including the Pasteurian revolution, the birth of
genetics, the emergence of molecular biology, and the latest
developments in biotechnology. He also explains the Nobel
Prize-winning prion hypothesis, which has rewritten the rules of
biological heredity and is a key link between the distinctive
diseases of TSE. Up-to-date, informative, and thoroughly
captivating, How the Cows Turned Mad tells the story of a disease
that continues to elude on many levels. Yet science has come far in
understanding its origins, incubation, and transmission. This
authoritative book is a stunning case history that illuminates the
remarkable progression of science.
Nervous And Mental Disease Monographs, No. 78.
A discerning guide to alternative therapies for common health
problems.
Millions of Americans turn to alternative medicine to treat
chronic health problems when conventional medicine fails. Yet few
doctors-or health store clerks and alternative practitioners-know
what treatments are safe and effective. In this book, Edward
Schneider, a leading researcher and clinician at the University of
Southern California, arms readers with an overview of the latest
medical research, then offers a proven formula for the best
integrative therapy available to treat the most common health
issues. From supplements and herbs, to acupuncture and yoga, "What
Your Doctor Hasn't Told You and the Health Store Clerk Doesn't
Know" outlines the myriad therapies used for:
- sleep problems
- joint, back, and neck pain
- depression and anxiety
- PMS and menopause
- prostate health
- heart disease and cancer
- memory loss, and more
An authoritative yet friendly guide, complete with hard-to-find
dosage guidelines and advice on what therapies are just not worth
your money, and packed with the type of information readers can
take to the health store aisles and to their doctor, this book is
essential reading for anyone considering alternative remedies
The "keys" provided by Herve Lacombe in this richly informed book
open the door to understanding the essence of nineteenth-century
French lyric theater. Lacombe illuminates the diverse elements that
constitute opera by focusing his investigation around three main
categories: composition and production; words, music, and drama;
and the interaction of society, genre, and aesthetics.
Lacombe chooses Bizet's "Pearl Fishers" (1863) as the exemplar of
French opera that combines tradition and innovation. He uses "Pearl
Fishers" as a paradigmatic point of reference for exploring
questions of genesis, style, and aesthetic in other
nineteenth-century French operatic works. French opera was a social
art, he writes, and looping between past and future, between
tradition and innovation, it achieved the seemingly impossible
union of two antithetical aspects of Romanticism: the taste for
theatricality and the desire for intimacy.
The voices of contemporary witnesses are heard throughout Lacombe's
book. He makes abundant use of the writings of such
musician-critics as Berlioz, Reyer, and Saint-Saens and also draws
on the works of many French writers, including Stendhal, Balzac,
Baudelaire, and Zola. Illustrations showing costume sketches,
scenery, posters, paintings, photographs, and magazine articles are
attractive complements to discussions of particular operas.
Together with Edward Schneider's accessible translation, the
illustrations make this well-rounded and original study a trove of
information for both music scholars and French historians.
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