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Pharmaceutical manufacture is very exacting - for example, drugs
must be uniform in size, shape, efficacy, bioavailability, and
safety. The presence of different polymorphs in drug production is
a serious problem, since different polymorphs differ in
bioavailability, solubility, dissolution rate, chemical and
physical stability, melting point, color, filterability, density,
and flow properties. Fine Particles in Medicine and Pharmacy
discusses particle size, shape, and composition and how they
determine the choice of polymorph of a drug.
The important role of ?nely dispersed matter and surfaces in
medicine is not always fully understood and appreciated.
Speci?cally, ?ne particles (solid or liquid) in the size range of
several nanometers to several micrometers have a tremendous effect
on our lives, because they can be bene?cial or detrimental to our
well-being. Such particles are present in living bodies as red
blood cells or cholesterol crystals in the gall bladder. They are
ubiquitous in the environment, where they can cause many diseases,
such as asbestosis, silicosis, and black lung disease, but they are
also used in diagnostic tests, drug delivery, and numerous other
applications. More recently, evidence has become available that
drug formulations with active components in a ?nely dispersed state
may signi?cantly affect their functionality. Furthermore, with
miniaturization of medical instrumentation, the size of the
components is necess- ily reduced to colloid or even smaller range.
This volume is a collection of several chapters dealing with
diverse topics of colloids and surfaces relevant to medical
applications. Thus, Siiman describes the use of optical properties
of uniform colloidal particles as probes in ?ow cytometry. Giesche
focuses on the preparations and properties of exceedingly uniform
silica spheres for different uses, such as in chromatography. In
modi?ed forms, silica p- ticles with incorporated dyes are employed
in diagnostics and those combined with tiny magnetic entities in
drug delivery.
The three sections of this volume deal with topics of broad
interest. The first deals with cetyl alcohol and is a most
comprehensive study of this essential ingredient in the cosmetic
and pharmaceutical industry, with an explanation of its
functionality. The second is a most comprehensive, up-to-date
review of acid/base interactions of a variety of materials,
including small molecules, proteins and polyelectrolytes. The third
section describes the combined radiochemical and electrochemical
methods in the evaluation of the properties of solids in contact
with solutions.
Ever since the first volume appeared in 1969, this series has
received good reviews in a variety of periodicals published in
different corners of 'the world. It would seem that the work has
fulfilled its purpose as outlined in the Preface to Volume 1. The
rapidly increasing interest in surface and colloid science by
people engaged in industrial research and development, and in
environmental, ecological, medical, pharmaceutical, and other
areas, justifies the continuation of such an effort. After nine
volumes with John Wiley and Sons, this and subsequent volumes
will-by mutual consent-be published by Plenum Press. The editor
will do his best to maintain and, if possible, improve the quality
of the contributions. While the fundamental philosophy will be
preserved, some moderate graphical changes have taken place. These
changes were done to enhance the readability and uniformity of the
volumes. Occasionally, volumes may appear under the editorship of
other scientists in the field. These volumes will be mainly devoted
to techniques in surface and colloid science. For reasons of
continuity a sequential numbering system will be used.
Taking a critical approach toward novel colloid systems and
phenomena, this series provides both the historical development and
a digest of recent advances. The current volume focuses on
solutions containing surfactants and polymers, with special
emphasis on micelle formation and microemulsions.
Ever since the first volume appeared in 1969, this series has
received good reviews in a variety of periodicals published in
different corners of the world. It would seem that the work has
fulfilled its purpose as outlined in the Preface to Volume 1. The
rapidly increasing interest in surface and colloid science by
people engaged in industrial research and development, and in
environmental, ecological, medical, pharmaceutical, and other
areas, justifies the continuation of such an effort. The Surface
and Colloid Science series originated with John Wiley and Sons and
has been continued with Plenum Press. This volume is the third with
the present publisher, and is the best assurance of our mutual
interest to proceed with this work. Some books in the series, as
was the case with Volume 11, may appear under the editorship of
other workers in the field. For reasons of continuity, a sequential
numbering system will be maintained. This editor hopes to provide
the scientific and technical community with high-quality
contributions in surface and colloid science in the future. He
invites specialists to submit definitive chapters on any topic
within the broad area of our discipline for inclusion in this
series.
Fisheries genetics researchers will find invaluable the
thirty-eight peer-reviewed contributions in this book, presented at
the 20th Lowell Wakefield Fisheries Symposium "Genetics of Subpolar
Fish and Invertebrates," held in May 2002 in Juneau, Alaska.
Looming over concerns of lost fisheries stocks and persistent
erosion of genetic variability are predictions of global warming,
which may further tax genetic resources. One consequence is an
increased reliance on genetic applications to many aspects of
fisheries management, aquaculture, and conservation. The
contributions in this book are important to modern fisheries
science and genetics, and illustrate the evolution of the field
over the past decade. The improved technology provides tools to
address increasingly complicated problems in traditional
applications and ecological and behavioral studies. The union
between molecular and quantitative genetics, where many of the
major questions about population structure and evolution remain
unanswered, will also benefit from the new technologies.
The three sections of this volume deal with topics of broad
interest. The first deals with cetyl alcohol and is a most
comprehensive study of this essential ingredient in the cosmetic
and pharmaceutical industry, with an explanation of its
functionality. The second is a most comprehensive, up-to-date
review of acid/base interactions of a variety of materials,
including small molecules, proteins and polyelectrolytes. The third
section describes the combined radiochemical and electrochemical
methods in the evaluation of the properties of solids in contact
with solutions.
Unlike previous volumes in the series for colloid and surface
scientists, revolves generally around two topics: surfactants and
polymers. The six papers discuss micelles of block and graft
copolymers in solutions, surfactant association in nonaqueous
media, a study of the boundary viscosity of organ
Pharmaceutical manufacture is very exacting - for example, drugs
must be uniform in size, shape, efficacy, bioavailability, and
safety. The presence of different polymorphs in drug production is
a serious problem, since different polymorphs differ in
bioavailability, solubility, dissolution rate, chemical and
physical stability, melting point, color, filterability, density,
and flow properties. Fine Particles in Medicine and Pharmacy
discusses particle size, shape, and composition and how they
determine the choice of polymorph of a drug.
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